Higgins R, Larivière S, Mittal K R, Martineau G P, Rousseau P, Cameron J
Can Vet J. 1985 Feb;26(2):86-9.
A bacterin containing serotypes 1 and 5 of Haemophilus pleuropneumoniae was developed for the prevention and the control of porcine pleuropneumonia. It was injected intramuscularly into three groups of ten piglets, the first group with one dose, the second one with two doses and the third one with three doses at two-week intervals. Another group of ten piglets did not receive the vaccine. All the piglets were then challenged by an aerosol of mixed suspensions of H. pleuropneumoniae serotypes 1 and 5. Two and three injections of vaccine completely prevented mortality, whereas half of the control piglets and of those receiving only one dose of vaccine died. All surviving piglets, both control and vaccinated, had severe signs of respiratory disease for at least 36 hours after exposure to challenge. Moreover, vaccination did not induce the production of antibodies at high titers. Local reactions were not noted after vaccination and at postmortem; ten weeks after the challenge, there were no signs of abscess formation or induration.
一种含有胸膜肺炎放线杆菌1型和5型血清型的菌苗被研发用于预防和控制猪胸膜肺炎。将其肌肉注射到三组每组十头仔猪中，第一组注射一剂，第二组注射两剂，第三组注射三剂，间隔两周注射一次。另一组十头仔猪未接种疫苗。然后所有仔猪通过吸入胸膜肺炎放线杆菌1型和5型混合悬液进行攻毒。注射两剂和三剂疫苗完全预防了死亡，而对照仔猪和仅接种一剂疫苗的仔猪中有一半死亡。所有存活的仔猪，无论是对照仔猪还是接种疫苗的仔猪，在接触攻毒后至少36小时都有严重的呼吸道疾病症状。此外，接种疫苗并未诱导产生高滴度抗体。接种疫苗后和剖检时未发现局部反应；攻毒十周后，没有脓肿形成或硬结的迹象。
