Bertelsen Mads F, Klausen Joan, Holm Elisabeth, Grøndahl Carsten, Jørgensen Poul H
Centre for Zoo and Wild Animal Health, Copenhagen Zoo, Roskildevej 38, DK-2000 Frederiksberg, Denmark.
Vaccine. 2007 May 30;25(22):4345-9. doi: 10.1016/j.vaccine.2007.03.043. Epub 2007 Apr 10.
Five hundred and forty birds in three zoos were vaccinated twice against avian influenza with a 6-week interval using an inactivated H5N9 vaccine. Serological response was evaluated by hemagglutination inhibition test 4-6 weeks following the second vaccine administration. 84% of the birds seroconverted, and 76% developed a titre > or =32. The geometric mean titre after vaccination was 137. A significant species variation in response was noted; penguins, pelicans, ducks, geese, herons, Guinea fowl, cranes, cockatiels, lovebirds, and barbets showed very poor response to vaccination, while very high titres and seroconversion rates were seen in flamingos, ibis, rheas, Congo peafowl, black-winged stilts, amazon parrots, and kookaburras.
三家动物园的540只鸟类使用灭活H5N9疫苗间隔6周进行了两次禽流感疫苗接种。在第二次疫苗接种后4 - 6周通过血凝抑制试验评估血清学反应。84%的鸟类发生血清转化，76%的鸟类产生了≥32的滴度。接种疫苗后的几何平均滴度为137。观察到明显的物种反应差异；企鹅、鹈鹕、鸭、鹅、鹭、珍珠鸡、鹤、鸡尾鹦鹉、情侣鹦鹉和拟啄木鸟对疫苗接种反应很差，而火烈鸟、朱鹭、美洲鸵鸟、刚果孔雀、黑翅长脚鹬、亚马逊鹦鹉和笑翠鸟则出现了非常高的滴度和血清转化率。
