Barsevick Andrea M
Nursing Research, Fax Chase Cancer Center, Philadelphia, PA, USA.
Semin Oncol Nurs. 2007 May;23(2):89-98. doi: 10.1016/j.soncn.2007.01.009.
To define the concept of a symptom cluster, evaluate the evidence base in support of it, and address research and clinical implications.
Review of descriptive research that examined fatigue, insomnia, pain, or depression in relation to other symptoms.
More investigation is needed. There is evidence of overlapping variance indicative of a relationship between or among symptoms. Few studies have addressed the outcomes of symptom clusters. There is limited evidence of symptom concurrence or a common biological pathway for clustered symptoms.
Consideration should be given to assessment and management of fatigue, insomnia, pain, and depression as potential "sentinel symptoms" that could affect patient outcomes.
定义症状群的概念，评估支持该概念的证据基础，并探讨其研究及临床意义。
对考察疲劳、失眠、疼痛或抑郁与其他症状关系的描述性研究进行综述。
需要进行更多研究。有证据表明存在重叠变异，提示症状之间存在关联。很少有研究探讨症状群的结局。关于症状同时出现或症状群存在共同生物学途径的证据有限。
应考虑将疲劳、失眠、疼痛和抑郁作为可能影响患者结局的潜在“哨兵症状”进行评估和管理。
