双侧眼眶髓系肉瘤作为急性髓系白血病的初始表现
Bilateral orbital myeloid sarcoma as initial manifestation of acute myeloid leukemia.
作者信息
Hmidi Kamel, Zaouali Sonia, Messaoud Riadh, Mahjoub Bahri, Ammari Wafa, Bacha Leila, Laatiri Adnene, Jenzeri Salah, Khairallah Moncef
机构信息
Department of Ophthalmology, Tahar Sfar University Hospital, Mahdia, Tunisia.
出版信息
Int Ophthalmol. 2007 Dec;27(6):373-7. doi: 10.1007/s10792-007-9088-z. Epub 2007 May 24.
BACKGROUND
Granulocytic sarcoma is a rare orbital complication of acute leukemia. It concerns primarily children under 10 years of age suffering from primitive acute myeloid leukemia. The diagnosis is made by clinical examination, computed tomography and confirmed by haematological investigations. The treatment approach is based on chemotherapy associated with intravenous steroid therapy.
CASE REPORT
We report the case of a 6-year-old girl who presented with bilateral proptosis revealing acute myeloid leukemia. The patient was treated by a combination of chemotherapeutic drugs in two phases, associated with intravenous steroids. After a follow-up period of 24 months, the patient was in complete remission.
CONCLUSION
The diagnosis of granulocytic sarcoma should be considered in any orbital mass of uncertain origin, particularly if it is bilateral. Special stains and immunohistochemistry play an important role in the diagnosis.
背景
粒细胞肉瘤是急性白血病一种罕见的眼眶并发症。主要涉及10岁以下患有原始急性髓系白血病的儿童。通过临床检查、计算机断层扫描进行诊断，并通过血液学检查加以证实。治疗方法基于化疗联合静脉类固醇治疗。
病例报告
我们报告了一名6岁女孩的病例，她因双侧眼球突出就诊，被诊断为急性髓系白血病。患者分两个阶段接受了化疗药物联合静脉类固醇治疗。经过24个月的随访，患者完全缓解。
结论
对于任何起源不明的眼眶肿物，尤其是双侧肿物，都应考虑粒细胞肉瘤的诊断。特殊染色和免疫组化在诊断中发挥重要作用。
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