烟草是慢性胰腺炎和酒精性肝硬化的风险因素吗？
Is tobacco a risk factor for chronic pancreatitis and alcoholic cirrhosis?
作者信息
Bourliere M, Barthet M, Berthezene P, Durbec J P, Sarles H
机构信息
Unité de recherches de Physiologie et de Pathologie Digestives, U 315 INSERM, Marseille, France.
出版信息
Gut. 1991 Nov;32(11):1392-5. doi: 10.1136/gut.32.11.1392.
In a case control study alcohol intake and tobacco use were assessed between 1975 and 1987 in 103 male patients suffering from alcoholic cirrhosis of the liver, in 145 patients with chronic pancreatitis, and in 264 control subjects. The patients with chronic pancreatitis were significantly younger than the patients with cirrhosis (mean (SD) age 41.92 (2.4) v 60.9 (11.6) years). Among the patients with chronic pancreatitis, 94% were both smokers and drinkers compared with 83% of patients with cirrhosis of the liver. The relative risks for each disease were calculated by conditional multiple logistic regression. Whereas daily intake of alcohol was a major risk factor for both cirrhosis of the liver and chronic pancreatitis, smoking was significantly related only to the risk of having chronic pancreatitis. Moreover, the mean age at onset of pancreatitis was lower among smokers.
在一项病例对照研究中，于1975年至1987年间对103例酒精性肝硬化男性患者、145例慢性胰腺炎患者以及264名对照者的酒精摄入量和烟草使用情况进行了评估。慢性胰腺炎患者明显比肝硬化患者年轻（平均（标准差）年龄41.92（2.4）岁对60.9（11.6）岁）。在慢性胰腺炎患者中，94%既吸烟又饮酒，而肝硬化患者中这一比例为83%。通过条件多因素逻辑回归计算每种疾病的相对风险。虽然每日酒精摄入量是肝硬化和慢性胰腺炎的主要危险因素，但吸烟仅与患慢性胰腺炎的风险显著相关。此外，吸烟者胰腺炎发病的平均年龄较低。
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