Knudtson Michael D, Klein Ronald, Klein Barbara E K
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA.
Am J Ophthalmol. 2007 Jun;143(6):1026-9. doi: 10.1016/j.ajo.2007.01.036.
To investigate alcohol consumption as a risk factor for the 15-year cumulative incidence and progression of age-related macular degeneration (AMD).
Prospective population-based study in Beaver Dam, WI with four examinations at five-year intervals initiated in 1988 (n = 3,509 contributed data for this analysis).
History of alcohol consumption was obtained via questionnaire. Cumulative incidence of early AMD, exudative AMD, pure geographic atrophy, and progression of AMD were assessed from fundus photographs taken at each examination.
Heavy drinking (four or more drinks daily) at baseline was related to the 15-year cumulative incidence of pure geographic atrophy in men (odds ratio, 9.2; 95% confidence interval, 1.7 to 51.2). There were no consistent associations with the amount of beer, wine, or liquor consumption and the incidence or progression of AMD.
Alcohol consumption is unlikely to strongly increase (or decrease) the risk of AMD.
研究饮酒作为年龄相关性黄斑变性（AMD）15年累积发病率及病情进展的危险因素。
在威斯康星州比弗代尔进行的基于人群的前瞻性研究，自1988年起每五年进行四次检查（本分析纳入了3509人的数据）。
通过问卷调查获取饮酒史。根据每次检查时拍摄的眼底照片评估早期AMD、渗出性AMD、单纯性地图样萎缩的累积发病率以及AMD的病情进展。
基线时大量饮酒（每日饮用四杯或更多）与男性单纯性地图样萎缩的15年累积发病率相关（比值比为9.2；95%置信区间为1.7至51.2）。啤酒、葡萄酒或烈酒的饮用量与AMD的发病率或病情进展之间没有一致的关联。
饮酒不太可能显著增加（或降低）AMD的风险。
