通过人嗜T淋巴细胞病毒II型（HTLV-II）形成合胞体，对CD4 + T细胞产生强烈细胞病变效应的CD8 + T细胞的转化。
Transformation of CD8+ T-cells producing a strong cytopathic effect on CD4+ T-cells through syncytium formation by HTLV-II.
作者信息
Miyamoto K, Kamiya T, Minowada J, Tomita N, Kitajima K
机构信息
School of Health Sciences, Okayama University.
出版信息
Jpn J Cancer Res. 1991 Nov;82(11):1178-83. doi: 10.1111/j.1349-7006.1991.tb01775.x.
Abstract
Human T-cell leukemia virus type II (HTLV-II) is thought to play an important role in the development of CD8+ T-cell malignancies resembling hairy cell leukemia. In this study, dramatic cytopathic effects characterized by syncytium formation in various CD4+ T-cell lines were observed upon their cocultivation with HTLV-II infected T-cells. The HTLV-II infected T-cells, however, did not die as a result of syncytium formation. HTLV-II also transformed CD4+ T-cells and CD8+ T-cells at various coculture ratios. Furthermore, sera from anti-HTLV-II antibody-positive specific carriers inhibited syncytium formation in the CD4+ T-cells. These results suggest that HTLV-II infection may contribute to the pathogenesis of associated CD8+ T-cell malignancies.
摘要
人类T细胞白血病病毒II型（HTLV-II）被认为在类似毛细胞白血病的CD8 + T细胞恶性肿瘤的发展中起重要作用。在本研究中，在各种CD4 + T细胞系与HTLV-II感染的T细胞共培养时，观察到以形成多核巨细胞为特征的显著细胞病变效应。然而，HTLV-II感染的T细胞不会因多核巨细胞形成而死亡。HTLV-II还以各种共培养比例转化CD4 + T细胞和CD8 + T细胞。此外，来自抗HTLV-II抗体阳性特异性携带者的血清可抑制CD4 + T细胞中的多核巨细胞形成。这些结果表明，HTLV-II感染可能与相关CD8 + T细胞恶性肿瘤的发病机制有关。
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