儿童HIV感染抗逆转录病毒治疗的依从性：一项定性系统评价及对研究和临床管理的建议
Adherence to antiretroviral therapy for pediatric HIV infection: a qualitative systematic review with recommendations for research and clinical management.
作者信息
Simoni Jane M, Montgomery Arianna, Martin Erin, New Michelle, Demas Penelope A, Rana Sohail
机构信息
Department of Psychology, University of Washington, Box 351525, Seattle, WA 98195-1525, USA.
出版信息
Pediatrics. 2007 Jun;119(6):e1371-83. doi: 10.1542/peds.2006-1232. Epub 2007 May 28.
Abstract
Although nonadherence to prescribed therapies is widespread, it is particularly problematic with highly active antiretroviral therapy for HIV infection. This review of >50 studies in the area of pediatric HIV infection revealed varying methods for assessing antiretroviral adherence with a wide range of estimates of adherence. Correlates of adherence could be grouped as those relating to the medication, the patient, and the caregiver/family, with many conflicting findings and a lack of theory guiding the research. Only 8 studies, mainly small feasibility or pilot investigations, evaluated highly active antiretroviral therapy adherence interventions in pediatric populations. We conclude with specific recommendations for assessment and clinical management of adherence and discuss directions for future research in this area.
摘要
尽管不遵守规定治疗的情况很普遍，但在用于治疗HIV感染的高效抗逆转录病毒疗法中，这一问题尤为突出。这篇对50多项儿科HIV感染领域研究的综述显示，评估抗逆转录病毒疗法依从性的方法各不相同，依从性估计范围也很广。依从性的相关因素可分为与药物、患者以及护理者/家庭相关的因素，存在许多相互矛盾的研究结果，且缺乏指导该研究的理论。只有8项研究（主要是小型可行性研究或试点调查）评估了儿科人群中高效抗逆转录病毒疗法的依从性干预措施。我们最后针对依从性的评估和临床管理提出了具体建议，并讨论了该领域未来的研究方向。
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