Asea Alexzander
Division of Investigative Pathology, Scott and White Clinic, Texas A&M University System Health Science Center College of Medicine, 2401 South 31st Street, Temple, TX 76508, USA.
J Biosci. 2007 Apr;32(3):579-84. doi: 10.1007/s12038-007-0057-5.
Currently two mechanisms are recognized by which heat shock proteins (HSP) are released from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma, surgery and following infection with lytic viruses, and an active release mechanism which involves the non classical protein release pathway. HSPs are released both as free HSP and within exosomes. This review covers recent findings on the mechanism by which stress induces the release of HSP72 into the circulation and the biological significance of circulating HSP72 to host defense against disease.
目前，人们认识到热休克蛋白（HSP）从细胞中释放有两种机制；一种是被动释放机制，包括坏死性细胞死亡、严重钝性创伤、手术以及感染裂解性病毒后，另一种是主动释放机制，涉及非经典蛋白质释放途径。热休克蛋白以游离热休克蛋白和外泌体的形式释放。本综述涵盖了关于应激诱导HSP72释放到循环中的机制以及循环HSP72对宿主抵御疾病的生物学意义的最新研究结果。
