Toft U, Kristoffersen L, Ladelund S, Bysted A, Jakobsen J, Lau C, Jørgensen T, Borch-Johnsen K, Ovesen L
Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Eur J Clin Nutr. 2008 Aug;62(8):1038-46. doi: 10.1038/sj.ejcn.1602815. Epub 2007 May 30.
To evaluate the validity of the Inter99 food frequency questionnaire (FFQ) compared with a 28-days' diet history and biomarkers.
A random sample of 13 016 individuals were drawn from a general population and invited for a health screening programme. Participation rate was 52.5%. All high-risk individuals were re-invited for assessment after 1 and 3 years and completed a 198-item FFQ at all three occasions. Participants attending for 3 years follow-up were invited to participate in the validation study, including a 28-days' diet history, a 24-h urine collection and a fasting blood sample. Overall, 264 subjects participated.
Spearman's rank correlation coefficients between the two dietary methods ranged from 0.31(beta-carotene) to 0.64 (fruits) in men and from 0.31 (polyunsaturated fat and sodium) to 0.64 (fruits) for women. The proportion of individuals classified in the same or adjacent quintiles were, on average, 72% for men and 69% for women. Gross misclassification was found on average in 2%. The correlation coefficients of the residuals ranged from 0.27 (sodium) to 0.61 (fruits) for men and from 0.21 (sodium) to 0.62 (B12-vitamin) for women. Correlation coefficients between fruit and vegetable intake and carotenoids ranged from -0.08 (lycopene) to 0.44 (alpha-carotene). For the residuals the correlation coefficients ranged from -0.004 (lycopene) to 0.47 (alpha-carotene).
The Inter99 FFQ and the residuals of the intake provide acceptable classification of individuals according to their dietary intakes and the FFQ gives a good quantitative measurement of key dietary components.
比较Inter99食物频率问卷（FFQ）与28天饮食史及生物标志物相比的有效性。
从普通人群中随机抽取13016名个体，邀请他们参加健康筛查项目。参与率为52.5%。所有高危个体在1年和3年后被再次邀请进行评估，并在所有三次评估时完成一份198项的FFQ。参加3年随访的参与者被邀请参加验证研究，包括28天饮食史、24小时尿液收集和空腹血样采集。总体而言，264名受试者参与了研究。
男性中两种饮食方法之间的斯皮尔曼等级相关系数范围为0.31（β-胡萝卜素）至0.64（水果），女性中为0.31（多不饱和脂肪和钠）至0.64（水果）。被归类在相同或相邻五分位数的个体比例，男性平均为72%，女性为69%。平均发现2%的个体存在严重错误分类。男性残差的相关系数范围为0.27（钠）至0.61（水果），女性为0.21（钠）至0.62（维生素B12）。水果和蔬菜摄入量与类胡萝卜素之间的相关系数范围为-0.08（番茄红素）至0.44（α-胡萝卜素）。对于残差，相关系数范围为-0.004（番茄红素）至0.47（α-胡萝卜素）。
Inter99 FFQ及其摄入量残差根据个体饮食摄入量提供了可接受的分类，并且FFQ对关键饮食成分给出了良好的定量测量。
