Huo Qun
Nanoscience Technology Center, Department of Chemistry University of Central Florida, 12424 Research Parkway, Orlando, FL 32826, USA.
Colloids Surf B Biointerfaces. 2007 Sep 1;59(1):1-10. doi: 10.1016/j.colsurfb.2007.04.019. Epub 2007 May 3.
Bioconjugated nanoparticles and quantum dots are among the most exciting nanomaterials with promising application potentials in nanomedicine field. These applications include biosensing, bioimaging, bioassay, targeted drug delivery and new therapeutic agents or method development. Although most of these applications are based on the optical properties of nanoparticle materials such as surface plasmon resonance, surface enhanced Raman scattering and strong photoluminescence, other aspects of nanoparticles such as the catalytic effect and amplification effect associated with the nanoscale dimension have also been explored. This review presents a narrative summary on the use of bioconjugated nanoparticles and quantum dots for biological applications, along with a discussion on some critical challenges existing in the field and possible solutions that have been or are being developed to overcome these challenges.
生物共轭纳米颗粒和量子点是纳米医学领域中最令人兴奋的纳米材料之一，具有广阔的应用潜力。这些应用包括生物传感、生物成像、生物检测、靶向药物递送以及新型治疗剂或方法的开发。尽管这些应用大多基于纳米颗粒材料的光学性质，如表面等离子体共振、表面增强拉曼散射和强荧光，但纳米颗粒的其他方面，如与纳米尺度相关的催化作用和放大作用，也已得到探索。本文综述了生物共轭纳米颗粒和量子点在生物应用方面的叙述性总结，同时讨论了该领域存在的一些关键挑战以及已经或正在开发的克服这些挑战的可能解决方案。
