Fattal Omar, Link Jessica, Quinn Kathleen, Cohen Bruce H, Franco Kathleen
Department of Psychiatry, Lutheran Hospital, Cleveland Clinic Health System, 1730 West 25th Street/2A, Cleveland, OH 44113, USA.
CNS Spectr. 2007 Jun;12(6):429-38. doi: 10.1017/s1092852900015303.
Mitochondria are intracellular organelles involved in adenosine triphosphate production. The literature has established the presence of mitochondrial dysfunction in some subjects with psychiatric disorders. Also, there are multiple reports of patients with mitochondrial dysfunction who have various psychiatric disorders. Although the literature on mitochondrial dysfunction and its relation to psychiatric disorders is growing, there remain many unanswered questions.
To review subjects with mitochondrial cytopathies for prevalence of psychiatric comorbidity.
For this study, 36 adults were interviewed. The Mini International Neuropsychiatric Interview and the Short-Form 36 Health Survey, version 1 were used.
Lifetime diagnoses included 54% major depressive disorder, 17% bipolar disorder, and 11% panic disorder. These prevalence rates are compared with the general population and subjects with cancer and epilepsy. Subjects with a comorbid psychiatric diagnosis were older (P=.05), had more hospital admissions (P=.02), more medical conditions (P=.01), and lower quality of life (P=.01) than subjects with mitochondrial disease alone.
Clinicians caring for persons with mitochondrial cytopathies should note the high prevalence of psychiatric problems. Also, this comorbidity might have etiological and therapeutic implications.
线粒体是参与三磷酸腺苷生成的细胞内细胞器。文献已证实一些患有精神疾病的受试者存在线粒体功能障碍。此外，有多项关于线粒体功能障碍患者患有各种精神疾病的报道。尽管关于线粒体功能障碍及其与精神疾病关系的文献不断增加，但仍有许多问题未得到解答。
回顾线粒体细胞病患者精神疾病共病的患病率。
本研究对36名成年人进行了访谈。使用了《迷你国际神经精神访谈》和第一版36项简明健康调查。
终生诊断包括54%的重度抑郁症、17%的双相情感障碍和11%的惊恐障碍。将这些患病率与普通人群、癌症患者和癫痫患者进行了比较。与仅患有线粒体疾病的受试者相比，患有精神疾病共病诊断的受试者年龄更大（P = 0.05）、住院次数更多（P = 0.02）、患有更多的疾病（P = 0.01）且生活质量更低（P = 0.01）。
照顾线粒体细胞病患者的临床医生应注意精神问题的高患病率。此外，这种共病可能具有病因学和治疗学意义。
