Al-Fakih Abdulkawi Ali, Almaqtri Wael Qasem Abdulgabbar
Department of Medical Microbiology, Faculty of Science, Ibb University, Ibb, Yemen.
Department of Chemistry, Faculty of Science, Ibb University, Ibb, Yemen.
Mycology. 2019 Apr 22;10(4):191-209. doi: 10.1080/21501203.2019.1604576. eCollection 2019.
Medicines developed from natural sources are a frequent target for the research and discovery of antimicrobial compounds. Discovering of penicillin in 1928 was a motive to explore of nature as a source of new antimicrobial agents. Fungi produce a diverse range of bioactive metabolites, making them rich source of different types of medicines. The purpose of this paper was to review studies on antibacterials from terrestrial published exclusively during 1942-2018, with emphasis on their antibacterial activities, structures, and mechanisms of action if present. According to the results from different studies in the world, large number of compounds and extracts showed different activities against different bacterial species, including Gram-positive and Gram-negative bacteria. The most prominent result was that of the compound CJ-17,665, isolated from , showing good activity against multi-drug resistant , which is well-recognised to be one of the most important current public health problem. These findings may motivate scientists to undertake a project that may result in the development of novel antibacterial drugs from terrestrial-derived spp., although further toxicity assays () must be performed before their application.
从天然来源开发的药物是抗菌化合物研究和发现的常见目标。1928年青霉素的发现促使人们探索自然界作为新型抗菌剂的来源。真菌产生多种生物活性代谢物，使其成为不同类型药物的丰富来源。本文的目的是综述1942年至2018年期间专门发表的关于陆生真菌抗菌剂的研究，重点关注其抗菌活性、结构以及作用机制（如有）。根据世界各地不同研究的结果，大量化合物和提取物对不同细菌种类表现出不同活性，包括革兰氏阳性菌和革兰氏阴性菌。最突出的结果是从[未提及的来源]分离出的化合物CJ - 17,665，对多重耐药菌表现出良好活性，而多重耐药菌是目前公认的最重要的公共卫生问题之一。这些发现可能促使科学家开展一个项目，有望从陆生[未提及的真菌种类]中开发出新型抗菌药物，不过在应用之前必须进行进一步的毒性试验（未提及具体试验）。
