Crosby Richard A, DiClemente Ralph J, Wingood Gina M, Salazar Laura F, Rose Eve, Sales Jessica M, Caliendo Angela M
Department of Health Behavior, College of Public Health, University of Kentucky, Lexington, KY 40506-0003, USA.
Sex Transm Infect. 2007 Jun;83(3):216-8. doi: 10.1136/sti.2006.022442.
To determine the association between oral contraceptive and condom use, and laboratory-confirmed sexually transmitted infection (STI) among African-American adolescent females at a high risk of STI acquisition.
A cross-sectional study of 715 African-American adolescent females (15-21 years old) was conducted. Data collection included (a) an audio-computer-assisted self-interview and a self-collected vaginal swab for nucleic acid amplification testing of Trichomonas vaginalis, Chlamydia trachomatis and Neisseria gonorrhoeae.
The age-adjusted odds ratio (AOR) indicated a modest protective effect of oral contraceptive use against unprotected vaginal sex (UVS) using a 60-day recall period (AOR = 0.66; 95% CI 0.43 to 0.99). The age-adjusted difference in mean frequency of UVS in the past 60 days was non-significant (p = 0.23) as was condom use at last sex (p = 0.34). The age-AOR relative to STI prevalence also showed a protective effect (AOR = 0.60; 95% CI 0.36 to 0.98) for those using oral contraceptives.
The findings suggest that the use of oral contraceptives may not preclude safer sex practices for the prevention of STIs among high-risk African-American adolescent females.
确定在获得性传播感染（STI）风险较高的非裔美国青少年女性中，口服避孕药和避孕套的使用与实验室确诊的性传播感染之间的关联。
对715名15至21岁的非裔美国青少年女性进行了横断面研究。数据收集包括：（a）通过音频计算机辅助自我访谈以及自行采集阴道拭子，用于对阴道毛滴虫、沙眼衣原体和淋病奈瑟菌进行核酸扩增检测。
年龄调整后的优势比（AOR）表明，使用口服避孕药对采用60天回忆期的无保护阴道性行为（UVS）有一定保护作用（AOR = 0.66；95%置信区间为0.43至0.99）。过去60天内无保护阴道性行为平均频率在年龄调整后的差异不显著（p = 0.23），最近一次性行为时使用避孕套的情况差异也不显著（p = 0.34）。相对于性传播感染患病率的年龄调整优势比也显示，使用口服避孕药者有保护作用（AOR = 0.60；95%置信区间为0.36至0.98）。
研究结果表明口服避孕药的使用可能无法排除高危非裔美国青少年女性为预防性传播感染而采取更安全性行为的必要性。
