North P E, Mihm M C
Department of Pathology, Univeristy of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas 72202, USA.
Facial Plast Surg Clin North Am. 2001 Nov;9(4):505-24.
Current histologic and immunophenotypic criteria useful in the pathological diagnosis of benign vascular tumors and anomalies of childhood, with emphasis on infantile hemangiomas and vascular and lymphatic malformations, have been described and correlated with clinical presentation. The authors have emphasized recent advances in research that portend an emerging revolution in our understanding of these perplexing lesions. These latter findings, particularly in the case of hemangiomas, suggest possible new preventive strategies and therapeutic avenues involving targeted use of angiogenic modulators.
目前用于儿童良性血管肿瘤和异常病理诊断的组织学和免疫表型标准已被描述，并与临床表现相关联，重点是婴儿血管瘤以及血管和淋巴管畸形。作者强调了近期研究进展，这些进展预示着我们对这些复杂病变的理解将迎来一场新的革命。这些最新发现，尤其是在血管瘤方面，提示了可能涉及靶向使用血管生成调节剂的新预防策略和治疗途径。
