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功能性肌管与生物微机电系统（Bio-MEMS）装置集成用于无创检测。

Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation.

作者信息

Wilson Kerry, Molnar Peter, Hickman James

机构信息

NanoScience Technology Center, University of Central Florida, Orlando, FL 32826, USA.

出版信息

Lab Chip. 2007 Jul;7(7):920-2. doi: 10.1039/b617939h. Epub 2007 Apr 20.

DOI:10.1039/b617939h
PMID:17594013
Abstract

We have developed a biological micro-electromechanical system (Bio-MEMS) device consisting of surface-modified microfabricated silicon cantilevers and an AFM detection apparatus for the study of cultured myotubes. With this system we are able to selectively stimulate the myotubes as well as report on a variety of physiological properties of the myotubes in real time and in a high-throughput manner. This system will serve as the foundation for future work integrating multiple tissue types for the creation of Bio-MEMS analogues of complex tissues and biological circuits.

摘要

我们开发了一种生物微机电系统（Bio-MEMS）装置，该装置由表面改性的微加工硅悬臂梁和用于研究培养肌管的原子力显微镜（AFM）检测设备组成。借助该系统，我们能够选择性地刺激肌管，并以高通量方式实时报告肌管的多种生理特性。该系统将为未来整合多种组织类型以创建复杂组织和生物电路的Bio-MEMS类似物的工作奠定基础。

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