Rautelin H, Renkonen O V, Kosunen T U
Department of Bacteriology and Immunology, University of Helsinki, Finland.
Antimicrob Agents Chemother. 1991 Oct;35(10):2065-9. doi: 10.1128/AAC.35.10.2065.
The in vitro susceptibilities of 102 human campylobacter strains isolated between 1978 and 1980 and 100 strains isolated in 1990 to ciprofloxacin, norfloxacin, erythromycin, gentamicin, and doxycycline were examined. The biotypes and heat-stable serotypes of the strains as well as antimicrobial treatments and travel history of the campylobacter-positive patients were also studied. The results indicated that susceptibility to erythromycin, gentamicin, and doxycycline has remained the same during the past 10 years. No gentamicin-resistant strains were found. Resistance to erythromycin was 3% in both groups of strains. However, the number of norfloxacin-resistant strains increased from 4 to 11% in the follow-up period, and ciprofloxacin-resistant strains, which had not occurred 10 years ago, composed 9% of the strains isolated in 1990. Thus, the increase of fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli has been significant in Finland in the past 10 years.
对1978年至1980年间分离出的102株人弯曲杆菌菌株以及1990年分离出的100株菌株进行了环丙沙星、诺氟沙星、红霉素、庆大霉素和强力霉素的体外药敏试验。还研究了这些菌株的生物型和热稳定血清型，以及弯曲杆菌阳性患者的抗菌治疗情况和旅行史。结果表明，在过去10年中，对红霉素、庆大霉素和强力霉素的敏感性保持不变。未发现耐庆大霉素的菌株。两组菌株对红霉素的耐药率均为3%。然而，在随访期间，耐诺氟沙星的菌株数量从4%增加到了11%，而10年前未出现的耐环丙沙星菌株在1990年分离出的菌株中占9%。因此，在过去10年中，芬兰空肠弯曲杆菌和结肠弯曲杆菌对氟喹诺酮类药物的耐药性显著增加。
