Alvarez Francisco J, Fyffe Robert E W
Department of Neuroscience, Cell Biology & Physiology, Boonshoft School of Medicine, Wright State University, 3640 Col. Glenn Hwy, Dayton, OH 45435, USA.
J Physiol. 2007 Oct 1;584(Pt 1):31-45. doi: 10.1113/jphysiol.2007.136200. Epub 2007 Jul 19.
Renshaw cell properties have been studied extensively for over 50 years, making them a uniquely well-defined class of spinal interneuron. Recent work has revealed novel ways to identify Renshaw cells in situ and this in turn has promoted a range of studies that have determined their ontogeny and organization of synaptic inputs in unprecedented detail. In this review we illustrate how mature Renshaw cell properties and connectivity arise through a combination of activity-dependent and genetically specified mechanisms. These new insights should aid the development of experimental strategies to manipulate Renshaw cells in spinal circuits and clarify their role in modulating motor output.
50多年来,人们对闰绍细胞的特性进行了广泛研究,使其成为一类定义明确的脊髓中间神经元。最近的研究工作揭示了原位识别闰绍细胞的新方法,这反过来又推动了一系列研究,以前所未有的详细程度确定了它们的个体发生和突触输入的组织方式。在这篇综述中,我们阐述了成熟的闰绍细胞特性和连接性是如何通过活动依赖和基因指定机制的结合而产生的。这些新见解将有助于开发实验策略来操纵脊髓回路中的闰绍细胞,并阐明它们在调节运动输出中的作用。