伦肖细胞的持续证据
The continuing case for the Renshaw cell.
作者信息
Alvarez Francisco J, Fyffe Robert E W
机构信息
Department of Neuroscience, Cell Biology & Physiology, Boonshoft School of Medicine, Wright State University, 3640 Col. Glenn Hwy, Dayton, OH 45435, USA.
出版信息
J Physiol. 2007 Oct 1;584(Pt 1):31-45. doi: 10.1113/jphysiol.2007.136200. Epub 2007 Jul 19.
Abstract
Renshaw cell properties have been studied extensively for over 50 years, making them a uniquely well-defined class of spinal interneuron. Recent work has revealed novel ways to identify Renshaw cells in situ and this in turn has promoted a range of studies that have determined their ontogeny and organization of synaptic inputs in unprecedented detail. In this review we illustrate how mature Renshaw cell properties and connectivity arise through a combination of activity-dependent and genetically specified mechanisms. These new insights should aid the development of experimental strategies to manipulate Renshaw cells in spinal circuits and clarify their role in modulating motor output.
摘要
50多年来，人们对闰绍细胞的特性进行了广泛研究，使其成为一类定义明确的脊髓中间神经元。最近的研究工作揭示了原位识别闰绍细胞的新方法，这反过来又推动了一系列研究，以前所未有的详细程度确定了它们的个体发生和突触输入的组织方式。在这篇综述中，我们阐述了成熟的闰绍细胞特性和连接性是如何通过活动依赖和基因指定机制的结合而产生的。这些新见解将有助于开发实验策略来操纵脊髓回路中的闰绍细胞，并阐明它们在调节运动输出中的作用。
相似文献
1
The continuing case for the Renshaw cell.伦肖细胞的持续证据
J Physiol. 2007 Oct 1;584(Pt 1):31-45. doi: 10.1113/jphysiol.2007.136200. Epub 2007 Jul 19.
2
Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.初级传入神经在Renshaw细胞上运动轴突突触数量发育调控中的作用。
J Comp Neurol. 2016 Jun 15;524(9):1892-919. doi: 10.1002/cne.23946. Epub 2016 Jan 4.
3
Primary afferent synapses on developing and adult Renshaw cells.发育中和成年伦肖细胞上的初级传入突触。
J Neurosci. 2006 Dec 20;26(51):13297-310. doi: 10.1523/jneurosci.2945-06.2006.
4
Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development.Pax6和engrailed 1调节闰绍细胞发育的两个不同方面。
J Neurosci. 2004 Feb 4;24(5):1255-64. doi: 10.1523/JNEUROSCI.3187-03.2004.
5
Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit.从 Renshaw 细胞和运动神经元回返性抑制回路中得到的中间神经元发育原理。
Ann N Y Acad Sci. 2013 Mar;1279:22-31. doi: 10.1111/nyas.12084.
6
Comparison of the morphological and electrotonic properties of Renshaw cells, Ia inhibitory interneurons, and motoneurons in the cat.猫中闰绍细胞、Ia抑制性中间神经元和运动神经元的形态学与电紧张特性比较
J Neurophysiol. 2003 Nov;90(5):2900-18. doi: 10.1152/jn.00533.2003. Epub 2003 Jul 23.
7
Target selection of proprioceptive and motor axon synapses on neonatal V1-derived Ia inhibitory interneurons and Renshaw cells.对新生儿 V1 衍生的 Ia 抑制性中间神经元和 Renshaw 细胞上的本体感觉和运动轴突突触的靶向选择。
J Comp Neurol. 2010 Dec 1;518(23):4675-701. doi: 10.1002/cne.22441.
8
9
Synaptic Connectivity between Renshaw Cells and Motoneurons in the Recurrent Inhibitory Circuit of the Spinal Cord.脊髓回返抑制回路中闰绍细胞与运动神经元之间的突触连接
J Neurosci. 2015 Oct 7;35(40):13673-86. doi: 10.1523/JNEUROSCI.2541-15.2015.
10
Regulation of gephyrin cluster size and inhibitory synaptic currents on Renshaw cells by motor axon excitatory inputs.运动轴突兴奋性输入对闰绍细胞上gephyrin簇大小和抑制性突触电流的调节
J Neurosci. 2005 Jan 12;25(2):417-29. doi: 10.1523/JNEUROSCI.3725-04.2005.
引用本文的文献
1
Synaptic imbalance and increased inhibition impair motor function in SMA.突触失衡和抑制增强损害脊髓性肌萎缩症的运动功能。
Sci Adv. 2025 Sep 5;11(36):eadt4126. doi: 10.1126/sciadv.adt4126.
2
Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.脊髓损伤中的中枢模式发生器：运动恢复的机制、调节及治疗策略
JOR Spine. 2025 Aug 11;8(3):e70100. doi: 10.1002/jsp2.70100. eCollection 2025 Sep.
3
Neurophysiological effects of latent trigger point dry needling on spinal reflexes.潜伏性触发点干针疗法对脊髓反射的神经生理效应
J Neurophysiol. 2025 Jan 1;133(1):288-298. doi: 10.1152/jn.00366.2024. Epub 2024 Dec 20.
4
Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity.脊髓 V1 抑制性中间神经元祖细胞在出生日期、向运动神经元的投射和异质性方面存在差异。
Elife. 2024 Nov 28;13:RP95172. doi: 10.7554/eLife.95172.
5
Restless Legs Syndrome in Hemodialysis Patients: Clinical and Electrophysiological Study.血液透析患者的不安腿综合征：临床与电生理研究
J Multidiscip Healthc. 2024 Nov 14;17:5251-5258. doi: 10.2147/JMDH.S483327. eCollection 2024.
6
Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis.在青蛙变态发育过程中，脊髓神经元的多样性随着从游泳到肢体运动的转变呈指数级增长。
bioRxiv. 2024 Sep 27:2024.09.20.614050. doi: 10.1101/2024.09.20.614050.
7
Synaptic imbalance and increased inhibition impair motor function in SMA.突触失衡和抑制增强会损害脊髓性肌萎缩症的运动功能。
bioRxiv. 2024 Sep 1:2024.08.30.610545. doi: 10.1101/2024.08.30.610545.
8
Spinal Basis of Direction Control during Locomotion in Larval Zebrafish.鱼类幼虫游动时方向控制的脊柱基础。
J Neurosci. 2023 May 31;43(22):4062-4074. doi: 10.1523/JNEUROSCI.0703-22.2023. Epub 2023 May 1.
9
Spinal Interneurons: Diversity and Connectivity in Motor Control.脊髓中间神经元：运动控制中的多样性和连通性。
Annu Rev Neurosci. 2023 Jul 10;46:79-99. doi: 10.1146/annurev-neuro-083122-025325. Epub 2023 Feb 28.
10
Humans at the dawn of the in-body electrical nerve stimulation era.处于体内电神经刺激时代开端的人类。
Facts Views Vis Obgyn. 2022 Dec;14(4):293-298. doi: 10.52054/FVVO.14.4.041.
本文引用的文献
1
Central effects of centripetal impulses in axons of spinal ventral roots.脊髓腹根轴突向心冲动的中枢效应。
J Neurophysiol. 1946 May;9:191-204. doi: 10.1152/jn.1946.9.3.191.
2
Primary afferent synapses on developing and adult Renshaw cells.发育中和成年伦肖细胞上的初级传入突触。
J Neurosci. 2006 Dec 20;26(51):13297-310. doi: 10.1523/jneurosci.2945-06.2006.
3
Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion.模拟参与运动模式生成的脊髓回路：来自虚拟运动过程中基因缺失的见解。
J Physiol. 2006 Dec 1;577(Pt 2):617-39. doi: 10.1113/jphysiol.2006.118703. Epub 2006 Sep 28.
4
Modelling spinal circuitry involved in locomotor pattern generation: insights from the effects of afferent stimulation.模拟参与运动模式生成的脊髓回路：来自传入刺激效应的见解。
J Physiol. 2006 Dec 1;577(Pt 2):641-58. doi: 10.1113/jphysiol.2006.118711. Epub 2006 Sep 28.
5
Locomotor circuits in the mammalian spinal cord.哺乳动物脊髓中的运动回路。
Annu Rev Neurosci. 2006;29:279-306. doi: 10.1146/annurev.neuro.29.051605.112910.
6
Activity of Renshaw cells during locomotor-like rhythmic activity in the isolated spinal cord of neonatal mice.新生小鼠离体脊髓中类运动节律活动期间闰绍细胞的活性。
J Neurosci. 2006 May 17;26(20):5320-8. doi: 10.1523/JNEUROSCI.5127-05.2006.
7
John Eccles' pioneering role in understanding central synaptic transmission.约翰·埃克尔斯在理解中枢突触传递方面的开创性作用。
Prog Neurobiol. 2006 Feb-Apr;78(3-5):173-88. doi: 10.1016/j.pneurobio.2006.02.002. Epub 2006 May 2.
8
Mobilizing the base of neuroscience data: the case of neuronal morphologies.整合神经科学数据基础：以神经元形态学为例。
Nat Rev Neurosci. 2006 Apr;7(4):318-24. doi: 10.1038/nrn1885.
9
V1 spinal neurons regulate the speed of vertebrate locomotor outputs.第一胸段脊髓神经元调节脊椎动物运动输出的速度。
Nature. 2006 Mar 9;440(7081):215-9. doi: 10.1038/nature04545.
10
Comparison of alpha2 nicotinic acetylcholine receptor subunit mRNA expression in the central nervous system of rats and mice.大鼠和小鼠中枢神经系统中α2烟碱型乙酰胆碱受体亚基mRNA表达的比较。
J Comp Neurol. 2005 Dec 12;493(2):241-60. doi: 10.1002/cne.20762.
Zotero 插件