Ihle J N, Domotor J J, Bengali K M
J Virol. 1976 Apr;18(1):124-31. doi: 10.1128/JVI.18.1.124-131.1976.
Normal sera from a variety of strains of inbred mice have precipitating antibodies to murine type C viruses that are detected by radioimmune precipitation assays. The results demonostrate that this humoral immune response is primarily directed against the AKR strain of murine leukemia virus (MuLV) proteins gp71, gp43, and p15(E). These sera also react with Friend- or Rauscher-MuLV in radioimmune precipitation assays. This reaction is not due to a separate immune response, but rather is primarily a consequence of the cross-reactivity of antibodies to the AKR strain of MuLV p15(E) with the p15(E) of these viruses. These data, using autogenous immune sera, emphasize the serological differences of the virion glycoproteins and the serological similarity of the p15(E) virion component of the viruses. Furthermore, based on the serological reactivities to the glycoproteins, the results suggest that the AKR strain of MuLV is endogenous to and expressed in mice, but that the Friend-Moloney-Rauscher virus group is not.
来自多种近交系小鼠品系的正常血清含有针对鼠C型病毒的沉淀抗体，这些抗体可通过放射免疫沉淀试验检测到。结果表明，这种体液免疫反应主要针对鼠白血病病毒（MuLV）AKR株的蛋白gp71、gp43和p15（E）。这些血清在放射免疫沉淀试验中也与Friend - 或Rauscher - MuLV发生反应。这种反应并非由于单独的免疫反应，而是主要由于针对MuLV AKR株p15（E）的抗体与这些病毒的p15（E）发生交叉反应的结果。这些使用自身免疫血清的数据强调了病毒粒子糖蛋白的血清学差异以及病毒p15（E）病毒粒子成分的血清学相似性。此外，基于对糖蛋白的血清学反应性，结果表明MuLV AKR株在小鼠体内是内源性的且可表达，但Friend - Moloney - Rauscher病毒组则不是。
