小鼠对内源性亲嗜性C型病毒包膜糖蛋白的天然免疫：病毒感染性的中和作用。
Natural immunity in mice to the envelope glycoprotein of endogenous ecotropic type C viruses: neutralization of virus infectivity.
作者信息
Ihle J N, Lazar B
出版信息
J Virol. 1977 Mar;21(3):974-80. doi: 10.1128/JVI.21.3.974-980.1977.
Abstract
The ability of naturally immune mouse sera to neutralize ecotropic AKR murine leukemia virus (MuLV) was examined by using unfrozen virus preparations harvested for 1 h. In this assay several mouse sera significantly and consistently neutralized MuLV infectivity. The ability of these sera to neutralize was correlated with the presence of antibodies against MuLV detectable in a radioimmune precipitation assay using radioactively labeled intact virions. This neutralization was specific, in that either N- or B-tropic viruses, but not Friend MuLV, were neutralized. In addition, neutralization could be abrogated with purified AKR MuLV gp71 at concentrations that do not interfere with virus infectivity but could not be abrogated with Rauscher MuLV gp71. Neutralizing activity could be removed by absorption with intact AKR MuLV, but not by absorption with Friend MuLV, a BALB/c xenotropic virus, or with NZB xenotropic virus. All the neutralizing activity of (B6C3)F1 mouse sera was associated with the immunoglobulin G fraction.
摘要
利用收获1小时的未冻存病毒制剂，检测天然免疫小鼠血清中和嗜亲性AKR鼠白血病病毒（MuLV）的能力。在此检测中，几种小鼠血清能显著且持续地中和MuLV的感染性。这些血清的中和能力与在使用放射性标记完整病毒体的放射免疫沉淀试验中可检测到的抗MuLV抗体的存在相关。这种中和作用具有特异性，即N嗜性或B嗜性病毒可被中和，但弗氏MuLV不能被中和。此外，用不干扰病毒感染性的浓度的纯化AKR MuLV gp71可消除中和作用，但用劳斯氏MuLV gp71则不能。中和活性可通过用完整的AKR MuLV吸收而去除，但不能通过用弗氏MuLV（一种BALB/c异嗜性病毒）或NZB异嗜性病毒吸收而去除。（B6C3）F1小鼠血清的所有中和活性都与免疫球蛋白G组分相关。
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