EasyGO：基于基因本体论的农艺物种注释与功能富集分析工具。
EasyGO: Gene Ontology-based annotation and functional enrichment analysis tool for agronomical species.
作者信息
Zhou Xin, Su Zhen
机构信息
Division of Bioinformatics, State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China.
出版信息
BMC Genomics. 2007 Jul 24;8:246. doi: 10.1186/1471-2164-8-246.
BACKGROUND
It is always difficult to interpret microarray results. Recently, a handful of tools have been developed to meet this need, but almost none of them were designed to support agronomical species.
DESCRIPTION
This paper presents EasyGO, a web server to perform Gene Ontology based functional interpretation on groups of genes or GeneChip probe sets. EasyGO makes a special contribution to the agronomical research community by supporting Affymetrix GeneChips of both crops and farm animals and by providing stronger capabilities for results visualization and user interaction. Currently it supports 11 agronomical plants, 3 farm animals, and the model plant Arabidopsis. The authors demonstrated EasyGO's ability to uncover hidden knowledge by analyzing a group of probe sets with similar expression profiles.
CONCLUSION
EasyGO is a good tool for helping biologists and agricultural scientists to discover enriched biological knowledge that can provide solutions or suggestions for original problems. It is freely available to all users at http://bioinformatics.cau.edu.cn/easygo/.
背景
解读微阵列结果一直很困难。最近，已经开发了一些工具来满足这一需求，但几乎没有一个是为支持农艺物种而设计的。
描述
本文介绍了EasyGO，一个用于对基因组或基因芯片探针集进行基于基因本体论的功能解读的网络服务器。EasyGO通过支持农作物和农场动物的Affymetrix基因芯片，并提供更强的结果可视化和用户交互能力，为农艺研究界做出了特殊贡献。目前它支持11种农艺植物、3种农场动物和模式植物拟南芥。作者通过分析一组具有相似表达谱的探针集，展示了EasyGO揭示隐藏知识的能力。
结论
EasyGO是帮助生物学家和农业科学家发现丰富生物知识的好工具，这些知识可以为原始问题提供解决方案或建议。所有用户均可在http://bioinformatics.cau.edu.cn/easygo/免费使用。
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