酒精饮料与肾细胞癌风险
Alcoholic beverages and risk of renal cell cancer.
作者信息
Greving J P, Lee J E, Wolk A, Lukkien C, Lindblad P, Bergström A
机构信息
Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
Br J Cancer. 2007 Aug 6;97(3):429-33. doi: 10.1038/sj.bjc.6603890. Epub 2007 Jul 24.
Using a mailed questionnaire, we investigated the risk of renal cell cancer in relation to different types of alcoholic beverages, and to total ethanol in a large population-based case-control study among Swedish adults, including 855 cases and 1204 controls. Compared to non-drinkers, a total ethanol intake of >620 g month(-1) was significantly related to a decreased risk of renal cell cancer (odds ratio (OR) 0.6, 95% confidence interval (CI) 0.4-0.9; P-value for trend=0.03). The risk decreased 30-40% with drinking more than two glasses per week of red wine (OR 0.6, 95% CI 0.4-0.9), white wine (OR 0.7, 95% CI 0.4-1.0), or strong beer (OR 0.6, 95% CI 0.4-1.0); there was a clear linear trend of decreasing risk with increasing consumption of these beverages (P-values for trends <0.05).
在一项针对瑞典成年人的大型基于人群的病例对照研究中，我们使用邮寄问卷调查了不同类型酒精饮料以及总乙醇摄入量与肾细胞癌风险之间的关系，该研究包括855例病例和1204名对照。与不饮酒者相比，每月总乙醇摄入量>620克与肾细胞癌风险降低显著相关（比值比（OR）为0.6，95%置信区间（CI）为0.4 - 0.9；趋势P值 = 0.03）。每周饮用超过两杯红酒（OR 0.6，95% CI 0.4 - 0.9）、白酒（OR 0.7，95% CI 0.4 - 1.0）或烈性啤酒（OR 0.6，95% CI 0.4 - 1.0），风险降低30 - 40%；随着这些饮料消费量的增加，风险呈明显的线性下降趋势（趋势P值<0.05）。
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