Glaser R, de Thé G, Lenoir G, Ho J H
Proc Natl Acad Sci U S A. 1976 Mar;73(3):960-3. doi: 10.1073/pnas.73.3.960.
Attempts were made to superinfect epithelial explant cell cultures prepared from nasopharyngeal carcinomas with Epstein-Barr virus. Virus-specific markers were observed in such cultures 3 days after superinfection. In addition, expression of Epstein-Barr virus early antigens was observed in epithelial cell explant cultures treated with iododeoxyuridine. The results suggest that epithelial cells of at least certain nasopharyngeal carcinomas possess the receptor for the Epstein-Barr virus and that the latent virus genome can be induced from epithelial cells prepared from such tumors.
尝试用爱泼斯坦-巴尔病毒对从鼻咽癌制备的上皮外植体细胞培养物进行再次感染。再次感染3天后，在这种培养物中观察到病毒特异性标志物。此外，在用碘脱氧尿苷处理的上皮细胞外植体培养物中观察到爱泼斯坦-巴尔病毒早期抗原的表达。结果表明，至少某些鼻咽癌的上皮细胞具有爱泼斯坦-巴尔病毒的受体，并且可以从由此类肿瘤制备的上皮细胞中诱导出潜伏的病毒基因组。
