血清克拉拉细胞蛋白16和表面活性蛋白-D在矽肺早期诊断及病情进展中的作用
Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis.
作者信息
Wang Shi-Xin, Liu Ping, Wei Mao-Ti, Chen Lei, Guo Yang, Wang Ran-Yang, Tu Zhi-Guang, Liang Xian-Cai
机构信息
Proteomics Laboratory, Medical College of Chinese People's Armed Police Force, Tianjin, China.
出版信息
J Occup Environ Med. 2007 Aug;49(8):834-9. doi: 10.1097/JOM.0b013e318124a927.
OBJECTIVE
To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis.
METHODS
Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay.
RESULTS
Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0 and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%.
CONCLUSION
Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.
目的
研究克拉拉细胞蛋白16（CC16）和表面活性蛋白-D（SP-D）作为血清生物标志物在矽肺早期诊断及发病机制中的作用。
方法
纳入30名健康志愿者、30名接触二氧化硅的工人以及30名疑似矽肺和一期矽肺的工人。采用酶联免疫吸附测定法测定血清CC16和SP-D浓度。
结果
与对照组相比，接触二氧化硅的工人血清CC16浓度降低，但血清SP-D水平升高，且在0期和I期组中这种趋势明显。判别分析显示，将组成员分类为对照组、0期、0期和I期的准确率分别为86.7%、46.7%、66.7%和70%，总分类准确率为67.5%。
结论
血清CC16和SP-D可能是早期诊断的有用生物标志物，血清SP-D浓度可能与矽肺的发病机制有关。
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