水性涂料释放的某些挥发性有机化合物的急性影响。
Acute effects of some volatile organic compounds emitted from water-based paints.
作者信息
Ernstgård Lena, Löf Agneta, Wieslander Gunilla, Norbäck Dan, Johanson Gunnar
机构信息
Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Occup Environ Med. 2007 Aug;49(8):880-9. doi: 10.1097/JOM.0b013e3181161ced.
OBJECTIVE
Acute effects during controlled exposure to some of the volatile organic compounds emitted from water-based paints were evaluated.
METHODS
Healthy volunteers (10 atopics, 10 nonatopics, and 10 painters) were exposed to a mixture of propyleneglycol, texanol, diethyleneglycol monoethylether, diethyleneglycol monobutyl ether, and dipropyleneglycol monomethyl ether at a total concentration of 35 mg/m3 (G), a mixture of G and ammonia (15 mg/m3) (GA), and clean air (C).
RESULTS
Subjective ratings of irritation in eyes, nose, throat, and dyspnea were significantly higher during the G and GA conditions, when compared with during the C condition. Nasal mucosal swelling was observed after G but not after GA exposure. No effects of the exposure on the pulmonary function, markers of inflammation in nasal lavages, and renal function in urine were seen.
CONCLUSION
Exposure to G and GA caused mild irritation in eyes, nose, and airways.
目的
评估在受控暴露于水性涂料释放的某些挥发性有机化合物期间的急性影响。
方法
健康志愿者（10名特应性个体、10名非特应性个体和10名油漆工）暴露于丙二醇、texanol、二乙二醇单乙醚、二乙二醇单丁醚和二丙二醇单甲醚的混合物，总浓度为35毫克/立方米（G），G与氨（15毫克/立方米）的混合物（GA），以及清洁空气（C）。
结果
与C条件相比，在G和GA条件下，眼睛、鼻子、喉咙的刺激主观评分以及呼吸困难评分显著更高。在G暴露后观察到鼻粘膜肿胀，但GA暴露后未观察到。未发现暴露对肺功能、鼻腔灌洗中的炎症标志物以及尿液中的肾功能有影响。
结论
暴露于G和GA会引起眼睛、鼻子和气道的轻度刺激。
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