Gregson N A, Jones D, Thomas P K, Willison H J
Department of Anatomy, United Medical School, Royal Free Hospital School of Medicine, London, UK.
J Neurol. 1991 Dec;238(8):447-51. doi: 10.1007/BF00314652.
We describe a 52-year-old man who had an acute-onset purely motor neuropathy fulfilling the diagnostic criteria for the Guillain-Barré syndrome, in whom virtually complete spontaneous recovery occurred by 1 year, and in whom high titres of polyclonal serum antibody to GM1, GD1b, asialo-GM1 and lacto-N-tetraose were detected. The titre of IgM antibody to GM1 fell during the course of the disease with a concomitant rise in the IgG titre. This case adds to the widening spectrum of disease associated with anti-GM1 antibodies and provides further evidence for a relationship between anti-GM1 antibodies and motor system disease.
我们描述了一名52岁男性，其患有急性起病的纯运动性神经病，符合吉兰-巴雷综合征的诊断标准，在1年内几乎完全自发恢复，且检测到其血清中针对GM1、GD1b、脱唾液酸GM1和乳糖-N-四糖的多克隆抗体滴度很高。在疾病过程中，针对GM1的IgM抗体滴度下降，同时IgG抗体滴度上升。该病例拓宽了与抗GM1抗体相关疾病的范围，并为抗GM1抗体与运动系统疾病之间的关系提供了进一步证据。
