Anninos P A, Tsagas N, Sandyk R, Derpapas K
Democrition University of Thrace, Department of Medical Physics and Polytechnic School, Alexandroupolis, Greece.
Int J Neurosci. 1991 Oct;60(3-4):141-71. doi: 10.3109/00207459109167029.
We have recently demonstrated that Magnetoencephalographic (MEG) brain measurements in patients with seizure disorders show significant MEG activity often in the absence of conventional EEG abnormalities. We localized foci of seizure activity using the mapping technique characterized by the ISO-Spectral Amplitude (ISO-SA) on the scalp distribution of specified spectral components or frequency bands of the emitted MEG Fourier power spectrum. In addition, using an electronic device, we utilized the above recorded activity to emit back the same intensity and frequency of magnetic field to the presumed epileptic foci. Using this method we were able, over the past two years, successfully to attenuate seizure activity in a cohort of over 100 patients with various forms of epilepsy. We now present in more detail three randomly selected patients with partial seizures in whom application of an external artificial magnetic field of low intensity produced a substantial attenuation of seizure frequency during an observation period extending from 10 to 14 months. All patients had previously obtained only partial response to conventional anticonvulsant therapy. Attenuation in seizure frequency was associated with normalization of the MEG activity. These cases demonstrate that artificial magnetic treatment may be a valuable adjunctive procedure in the management of partial seizures. The possible mechanisms underlying the anticonvulsant properties of magnetic stimulation at both cellular and systemic levels are discussed. Specifically, since the pineal gland has been shown to be a magnetosensitive organ which forms part of a combined compass-solar clock system, and since it exerts an inhibitory action on seizure activity in both experimental animals and humans, we discuss the potential pivotal role of the pineal gland in the long term anticonvulsant effects of external artificial magnetic stimulation.
我们最近证明，癫痫患者的脑磁图（MEG）脑部测量显示，在没有传统脑电图异常的情况下，往往存在显著的MEG活动。我们使用以等谱振幅（ISO-SA）为特征的映射技术，在发射的MEG傅里叶功率谱的特定频谱成分或频段的头皮分布上定位癫痫活动病灶。此外，我们使用一种电子设备，利用上述记录的活动，将相同强度和频率的磁场发射回假定的癫痫病灶。在过去两年中，使用这种方法，我们成功地减轻了100多名患有各种形式癫痫的患者的癫痫活动。现在，我们更详细地介绍三名随机选择的部分性癫痫患者，在10至14个月的观察期内，施加低强度的外部人工磁场可使癫痫发作频率大幅降低。所有患者此前对传统抗惊厥治疗仅获得部分缓解。癫痫发作频率的降低与MEG活动的正常化相关。这些病例表明，人工磁疗可能是治疗部分性癫痫的一种有价值的辅助手段。本文讨论了磁刺激在细胞和全身水平上抗惊厥特性的潜在机制。具体而言，由于松果体已被证明是一个磁敏器官，它是罗盘 - 太阳时钟组合系统的一部分，并且由于它在实验动物和人类中都对癫痫活动发挥抑制作用，我们讨论了松果体在外部人工磁刺激的长期抗惊厥作用中的潜在关键作用。
