儿童中I型人类冠状病毒的血清流行病学
Seroepidemiology of group I human coronaviruses in children.
作者信息
Shao Xiuping, Guo Xiaojie, Esper Frank, Weibel Carla, Kahn Jeffrey S
机构信息
Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
J Clin Virol. 2007 Nov;40(3):207-13. doi: 10.1016/j.jcv.2007.08.007. Epub 2007 Sep 21.
BACKGROUND
Recently, several new human coronaviruses have been identified.
OBJECTIVES
To define the seroepidemiology of group I human coronaviruses.
STUDY DESIGN
A recombinant protein enzyme linked immunosorbent assay (ELISA) based on portions of the nucleocapsid protein of group I human coronaviruses was developed and was used to screen serum from 243 children and young adults.
RESULTS
For HCoV-229E, the percentages of seropositive individuals were 57.1% for infants <2 months old; 38.9% for infants 2-3 months old; 4.7% for infants 4-5 months old; 42.9-50.0% for infants 6-12 months old; 34.8-62.5% for individuals 1-20 years old. For HCoV-NL63, the percentages of seropositive individuals were 45.2% for infants <2 months old; 11.1% for infants 2-3 months old; 4.7% for infants 4-5 months old; 28.6-40.0% for infants 6-12 months old; 25.0-70.3% for individuals 1-20 years old.
CONCLUSIONS
Infection with these viruses is common in childhood though the prevalence of these viruses may vary from year to year.
背景
最近，几种新型人类冠状病毒已被鉴定出来。
目的
确定I组人类冠状病毒的血清流行病学。
研究设计
开发了一种基于I组人类冠状病毒核衣壳蛋白部分的重组蛋白酶联免疫吸附测定（ELISA），并用于筛查243名儿童和年轻人的血清。
结果
对于HCoV - 229E，血清阳性个体的百分比在2个月以下婴儿中为57.1%；2 - 3个月婴儿中为38.9%；4 - 5个月婴儿中为4.7%；6 - 12个月婴儿中为42.9 - 50.0%；1 - 20岁个体中为34.8 - 62.5%。对于HCoV - NL63，血清阳性个体的百分比在2个月以下婴儿中为45.2%；2 - 3个月婴儿中为11.1%；4 - 5个月婴儿中为4.7%；6 - 12个月婴儿中为28.6 - 40.0%；1 - 20岁个体中为25.0 - 70.3%。
结论
这些病毒的感染在儿童期很常见，尽管这些病毒的流行率可能逐年变化。
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