大鼠和小鼠细胞中存在缺陷的类逆转录病毒30S RNA种类，若被C型辅助病毒包装则具有感染性。
Defective retrovirus-like 30S RNA species of rat and mouse cells are infectious if packaged by type C helper virus.
作者信息
Scolnick E M, Vass W C, Howk R S, Duesberg P H
出版信息
J Virol. 1979 Mar;29(3):964-72. doi: 10.1128/JVI.29.3.964-972.1979.
Abstract
RNA species with properties of defective retrovirus-like 30S RNA genomes have previously been detected in both rats and mice and in some rat and mouse retroviruses. Using cell lines which express high levels of this retrovirus-like RNA, we formed pseudotypes of the 30S RNAs with helper-independent type C viruses. A pseudotype virus complex containing a mouse 30S subunit was transmitted to rat cells, and a pseudotype virus complex containing a rat 30S subunit was transmitted to bat cells. In other transmission experiments, a rat 30S subunit was isolated in nonproducer bat cells without detectable expression of the helper-independent type C virus used to pseudotype it. The results provide further support for the retrovirus-like nature of the rat 30S subunit and provide evidence which supports the protovirus hypothesis proposed by Temin.
摘要
此前已在大鼠和小鼠以及一些大鼠和小鼠逆转录病毒中检测到具有缺陷性逆转录病毒样30S RNA基因组特性的RNA种类。利用表达高水平这种逆转录病毒样RNA的细胞系，我们用非依赖辅助病毒的C型病毒形成了30S RNA的假型。含有小鼠30S亚基的假型病毒复合物被传递给大鼠细胞，含有大鼠30S亚基的假型病毒复合物被传递给蝙蝠细胞。在其他传递实验中，在不产生病毒的蝙蝠细胞中分离出大鼠30S亚基，而用于形成其假型的非依赖辅助病毒的C型病毒未检测到表达。这些结果为大鼠30S亚基的逆转录病毒样性质提供了进一步支持，并为特明提出的原病毒假说提供了支持证据。
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