使用相同磁共振成像（MR）系统对一项运动任务进行多部位功能磁共振成像（fMRI）的可重复性。
Multisite fMRI reproducibility of a motor task using identical MR systems.
作者信息
Costafreda Sergi G, Brammer Michael J, Vêncio Ricardo Z N, Mourão Maria L, Portela Luiz A P, de Castro Claudio Campi, Giampietro Vincent P, Amaro Edson
机构信息
Brain Image Analysis Unit, Institute of Psychiatry, King's College London, UK.
出版信息
J Magn Reson Imaging. 2007 Oct;26(4):1122-6. doi: 10.1002/jmri.21118.
PURPOSE
To estimate between-scanner functional MRI (fMRI) reproducibility in a multisite study.
MATERIALS AND METHODS
A total of five identical 1.5T MR systems were used to repeatedly scan five subjects while performing a finger tapping task. A two-way (scanners, subjects) random effects analysis of variance (ANOVA) was used to estimate between-scanner and between-subject variability on two outcome variables: task-related mean blood oxygenation level dependent (BOLD) signal change and volume of activation within a motor region-of-interest (ROI).
RESULTS
Between-scanner variability of fMRI data accounted for a small proportion of the total variation in the BOLD signal change (8.34%, P = 0.114) and volume of activation (5.46%, P = 0.203). Between-subject variation accounted for more than half of the total variation for both measurements (57.17% and 54.46%, respectively, P < 0.01).
CONCLUSION
These results support the feasibility of multisite studies using identical scanner systems.
目的
在一项多中心研究中评估不同扫描仪之间功能磁共振成像（fMRI）的可重复性。
材料与方法
使用五台相同的1.5T磁共振成像系统，在五名受试者执行手指轻敲任务时进行重复扫描。采用双向（扫描仪、受试者）随机效应方差分析（ANOVA），以评估两个结果变量在不同扫描仪之间以及不同受试者之间的变异性：与任务相关的平均血氧水平依赖（BOLD）信号变化以及运动感兴趣区域（ROI）内的激活体积。
结果
fMRI数据在不同扫描仪之间的变异性在BOLD信号变化的总变异中占比很小（8.34%，P = 0.114），在激活体积的总变异中占比也很小（5.46%，P = 0.203）。在这两项测量中，不同受试者之间的变异均占总变异的一半以上（分别为57.17%和54.46%，P < 0.01）。
结论
这些结果支持了使用相同扫描仪系统进行多中心研究的可行性。
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