Vural Emre, Winfield Harry L, Shingleton Alexander W, Horn Thomas D, Shafirstein Gal
Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 543, Little Rock, AR 72205, USA.
Lasers Med Sci. 2008 Oct;23(4):349-53. doi: 10.1007/s10103-007-0492-4. Epub 2007 Sep 28.
The effects of various laser wavelengths and fluences on the fungal isolate, Trichophyton rubrum, were examined in vitro. Standard-size isolates of T. rubrum were irradiated by using various laser systems. Colony areas were compared for growth inhibition on days 1, 3, and 6 after laser irradiation. Statistically significant growth inhibition of T. rubrum was detected in colonies treated with the 1,064-nm Q-switched Nd:YAG laser at 4 and 8 J/cm(2) and 532-nm Q-switched Nd:YAG laser at 8 J/cm(2). Q-switched Nd:YAG laser at 532- and 1,064-nm wavelengths produced significant inhibitory effect upon the fungal isolate T. rubrum in this in vitro study. However, more in vitro and in vivo studies are necessary to investigate if lasers would have a potential use in the treatment of fungal infections of skin and its adnexa.
在体外研究了不同激光波长和能量密度对红色毛癣菌分离株的影响。使用各种激光系统对标准大小的红色毛癣菌分离株进行照射。比较激光照射后第1、3和6天菌落面积的生长抑制情况。在用4 J/cm(2)和8 J/cm(2)的1,064纳米调Q Nd:YAG激光以及8 J/cm(2)的532纳米调Q Nd:YAG激光处理的菌落中，检测到红色毛癣菌有统计学意义的生长抑制。在这项体外研究中，532纳米和1,064纳米波长的调Q Nd:YAG激光对红色毛癣菌分离株产生了显著的抑制作用。然而，需要更多的体外和体内研究来调查激光是否有可能用于治疗皮肤及其附属器的真菌感染。
