Rainer Alberto, Giannitelli Sara Maria, Abbruzzese Franca, Traversa Enrico, Licoccia Silvia, Trombetta Marcella
CIR - Laboratory of Chemistry and Biomaterials, University Campus Bio-Medico of Rome, via Alvaro del Portillo 21, 00128 Roma, Italy.
Acta Biomater. 2008 Mar;4(2):362-9. doi: 10.1016/j.actbio.2007.08.007. Epub 2007 Aug 31.
A technique for the preparation of bioglass foams for bone tissue engineering is presented. The process is based on the in situ foaming of a bioglass-loaded polyurethane foam as the intermediate step for obtaining a bioglass porous monolith, starting from sol-gel synthesized bioglass powders. The obtained foams were characterized using X-ray diffraction analysis, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy observations. The material was assessed by soaking samples in simulated body fluid and observing apatite layer formation. Diagnostic imaging taken from human patients was used to reconstruct a human bone portion, which was used to mould a tailored scaffold fabricated using the in situ foaming technique. The results confirmed that the obtained bioactive materials prepared with three-dimensional processing are promising for applications in reconstructive surgery tailored to each single patient.
介绍了一种用于骨组织工程的生物玻璃泡沫制备技术。该工艺基于负载生物玻璃的聚氨酯泡沫原位发泡，这是从溶胶-凝胶合成的生物玻璃粉末开始获得生物玻璃多孔整体材料的中间步骤。使用X射线衍射分析、傅里叶变换红外光谱和场发射扫描电子显微镜观察对所得泡沫进行了表征。通过将样品浸泡在模拟体液中并观察磷灰石层的形成来评估该材料。利用从人类患者身上获取的诊断成像来重建人类骨骼部分，该部分用于模制使用原位发泡技术制造的定制支架。结果证实，通过三维加工制备的所得生物活性材料在针对每个患者量身定制的重建手术中具有应用前景。
