γ-氨基丁酸A（GABA(A)）受体参与茶氨酸对小鼠局灶性脑缺血的神经保护作用。
Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice.
作者信息
Egashira Nobuaki, Hayakawa Kazuhide, Osajima Megumi, Mishima Kenichi, Iwasaki Katsunori, Oishi Ryozo, Fujiwara Michihiro
机构信息
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
出版信息
J Pharmacol Sci. 2007 Oct;105(2):211-4. doi: 10.1254/jphs.scz070901. Epub 2007 Oct 6.
We investigated the involvement of gamma-aminobutyric acid(A) (GABA(A)) receptors in the neuroprotective effect of gamma-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABA(A)-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA(A) receptors.
我们研究了γ-氨基丁酸A（GABA(A)）受体在γ-谷氨酰乙酰胺（茶氨酸）的神经保护作用中的参与情况，茶氨酸是日本绿茶的一种成分，在小鼠大脑中动脉（MCA）闭塞4小时后进行研究。茶氨酸（1毫克/千克）在MCA闭塞后24小时减小了脑梗死体积，并降低了NeuN、GFAP和Iba 1表达水平的改变。茶氨酸的这种神经保护作用被荷包牡丹碱（GABA(A)受体拮抗剂，10毫克/千克）阻断，但未被3-巯基丙酸（谷氨酸脱羧酶抑制剂）阻断。这些结果表明，茶氨酸的神经保护作用至少部分是由GABA(A)受体介导的。
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