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从中国中部分离出的甲型流感病毒A/鸭/湖北/W1/2004（H9N2）的进化特征

Evolutionary characterization of influenza virus A/duck/Hubei/W1/2004 (H9N2) isolated from central China.

作者信息

Xu Xiao-Juan, Xu Gao-Yuan, Zhou Hong-Bo, Yu Zheng-Jun, Zhang An-Ding, Song Yun-Feng, Jin Mei-Lin, Chen Huan-Chun

机构信息

Division of Animal Infectious Diseases, National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, PR China.

出版信息

Virus Genes. 2008 Feb;36(1):79-83. doi: 10.1007/s11262-007-0123-y. Epub 2007 Nov 20.

DOI:10.1007/s11262-007-0123-y
PMID:18027082
Abstract

Full-length eight gene segments of avian influenza virus A/duck/Hubei/W1/2004(H9N2) (Dk/Hub/W1/04) were amplified by RT-PCR and completely sequenced. Phylogenetic analysis revealed that Dk/Hub/W1/04 was derived from A/Duck/HongKong/Y280/97, not displaying direct evolutional relationship with A/Quail/HongKong/G1/97 or Hubei H5N1 viruses. Meanwhile, Dk/Hub/W1/04 was found highly related to recent three chicken isolates. The connecting peptide of HA and the deletion in NA stalk were consistent with three chicken isolates, and the number of potential glycosylation site on the HA and NA also was similar or identical to the three chicken isolates. These findings suggested that Dk/Hub/W1/04 is likely to transmit back to ducks from chickens.

摘要

通过逆转录聚合酶链反应（RT-PCR）扩增了甲型禽流感病毒A/鸭/湖北/W1/2004（H9N2）（Dk/Hub/W1/04）的全长八个基因片段，并进行了全序列测定。系统发育分析表明，Dk/Hub/W1/04源自A/鸭/香港/Y280/97，与A/鹌鹑/香港/G1/97或湖北H5N1病毒没有直接进化关系。同时，发现Dk/Hub/W1/04与最近的三株鸡分离株高度相关。血凝素（HA）的连接肽和神经氨酸酶（NA）柄部的缺失与三株鸡分离株一致，HA和NA上潜在糖基化位点的数量也与三株鸡分离株相似或相同。这些发现表明，Dk/Hub/W1/04可能从鸡反向传播回鸭。

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