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1
Toll-like receptors and leishmaniasis.Toll样受体与利什曼病。
Infect Immun. 2008 Mar;76(3):866-72. doi: 10.1128/IAI.01090-07. Epub 2007 Dec 10.
2
Transmission blocking vaccine studies in leishmaniasis: II. Effect of immunisation using Leishmania major derived 63 kilodalton glycoprotein, lipophosphoglycan and whole parasite antigens on the course of L. major infection in BALB/c mice.利什曼病的传播阻断疫苗研究：II. 使用硕大利什曼原虫来源的63千道尔顿糖蛋白、脂磷壁酸糖和全寄生虫抗原免疫对BALB/c小鼠硕大利什曼原虫感染进程的影响。
East Afr Med J. 2001 Feb;78(2):90-2.
3
Analysis of the human T cell responsiveness to purified antigens of Leishmania: lipophosphoglycan (LPG) and glycoprotein 63 (gp 63).人类T细胞对利什曼原虫纯化抗原：脂磷壁酸聚糖（LPG）和糖蛋白63（gp 63）的反应性分析。
Clin Exp Immunol. 1991 Mar;83(3):472-8. doi: 10.1111/j.1365-2249.1991.tb05663.x.
4
[Parasitic evasion mechanisms: Leishmania as an example].[寄生虫逃避机制：以利什曼原虫为例]
Immun Infekt. 1989 Aug;17(4):129-40.
5
The interface between the Leishmania-infected macrophage and the host's immune system.利什曼原虫感染的巨噬细胞与宿主免疫系统之间的界面。
Behring Inst Mitt. 1991 Feb(88):68-79.
6
Characterization of T cell responses to purified leishmania antigens in subjects infected with Leishmania chagasi.感染恰加斯利什曼原虫的受试者中T细胞对纯化利什曼原虫抗原反应的特征分析。
Braz J Med Biol Res. 1994 May;27(5):1199-205.
7
Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients.人类T细胞对利什曼原虫抗原反应的二分法。II. 治愈的内脏利什曼病患者细胞对gp63无反应或呈Th2样反应，而对脂磷壁酸相关蛋白呈Th1样反应
Clin Exp Immunol. 1994 Jun;96(3):416-21. doi: 10.1111/j.1365-2249.1994.tb06044.x.
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[Protective effects of leishmanial antigens against Leishmania infantum infection in Lagurus lagurus].[利什曼原虫抗原对草原兔尾鼠婴儿利什曼原虫感染的保护作用]
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1999;17(4):237-40.
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Absence of a proven resurgence of Chagas disease or cutaneous leishmaniasis in French Guiana over the last two decades.在过去二十年中，法属圭亚那没有查加斯病或皮肤利什曼病确诊复发的情况。
Ann Trop Med Parasitol. 2001 Sep;95(6):623-5. doi: 10.1080/00034980120092561.
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Toll-like receptor signaling: a perspective to develop vaccine against leishmaniasis.Toll 样受体信号通路：开发利什曼病疫苗的新视角。
Microbiol Res. 2012 Sep 6;167(8):445-51. doi: 10.1016/j.micres.2012.01.002. Epub 2012 Feb 10.

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Immunoinformatic approach to the design of a novel multi-epitope vaccine against fused to human IgG-Fc.一种针对与人类IgG-Fc融合的新型多表位疫苗设计的免疫信息学方法。
Res Pharm Sci. 2024 Dec 15;19(6):729-745. doi: 10.4103/RPS.RPS_145_24. eCollection 2024 Dec.
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MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis.MR1 阻断基于循环免疫细胞和可溶性介质的电路对内脏利什曼病综合特征产生差异影响。
Front Immunol. 2024 Aug 13;15:1373498. doi: 10.3389/fimmu.2024.1373498. eCollection 2024.
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A novel approach to design chimeric multi epitope vaccine against exploiting infected host cell proteome.一种利用受感染宿主细胞蛋白质组设计嵌合多表位疫苗的新方法。
Heliyon. 2024 May 17;10(10):e31306. doi: 10.1016/j.heliyon.2024.e31306. eCollection 2024 May 30.
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mRNA expression of immune factors by milk somatic cells from healthy Holstein lactating cows.健康荷斯坦泌乳奶牛乳体细胞免疫因子的 mRNA 表达。
Can J Vet Res. 2023 Jul;87(3):231-236.
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The Immunological Changes in the Skin of BALC/c Mice with Disseminated Acanthamoebiasis.播散性棘阿米巴病BALC/c小鼠皮肤的免疫学变化
Pathogens. 2023 Apr 22;12(5):631. doi: 10.3390/pathogens12050631.
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In silico designing of a novel polyvalent multi-subunit peptide vaccine leveraging cross-immunity against human visceral and cutaneous leishmaniasis: an immunoinformatics-based approach.基于免疫信息学的方法：利用针对人体内脏利什曼病和皮肤利什曼病的交叉免疫原性，设计新型多价多亚单位肽疫苗。
J Mol Model. 2023 Mar 16;29(4):99. doi: 10.1007/s00894-023-05503-w.
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Immunoinformatics Studies and Design of a Potential Multi-Epitope Peptide Vaccine to Combat the Fatal Visceral Leishmaniasis.用于对抗致命内脏利什曼病的潜在多表位肽疫苗的免疫信息学研究与设计
Vaccines (Basel). 2022 Sep 22;10(10):1598. doi: 10.3390/vaccines10101598.
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Case Report: Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Receiving Methotrexate.病例报告：接受甲氨蝶呤治疗的类风湿关节炎患者罹患皮肤利什曼病。
Am J Trop Med Hyg. 2022 Sep 6;107(4):785-788. doi: 10.4269/ajtmh.22-0180. Print 2022 Oct 12.
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Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids.激活TLR通路以诱导宿主针对内脏利什曼病的Th1免疫反应：半乳糖基化黄酮类化合物的作用。
Heliyon. 2022 Jul 3;8(7):e09868. doi: 10.1016/j.heliyon.2022.e09868. eCollection 2022 Jul.
10
The pathogenicity and virulence of Leishmania - interplay of virulence factors with host defenses.利什曼原虫的致病性和毒力——毒力因子与宿主防御的相互作用。
Virulence. 2022 Dec;13(1):903-935. doi: 10.1080/21505594.2022.2074130.

本文引用的文献

1
Mucosal leishmaniasis . Current scenario and prospects for treatment.黏膜利什曼病。当前的情况及治疗前景。
Acta Trop. 2008 Jan;105(1):1-9. doi: 10.1016/j.actatropica.2007.08.003. Epub 2007 Aug 19.
2
Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase.中性粒细胞通过中性粒细胞弹性蛋白酶募集Toll样受体4（TLR4）来激活巨噬细胞，从而对硕大利什曼原虫进行胞内杀伤。
J Immunol. 2007 Sep 15;179(6):3988-94. doi: 10.4049/jimmunol.179.6.3988.
3
Treatment of mucosal leishmaniasis in Latin America: systematic review.拉丁美洲黏膜利什曼病的治疗：系统评价
Am J Trop Med Hyg. 2007 Aug;77(2):266-74.
4
Cutaneous leishmaniasis reactivation 2 years after treatment caused by systemic corticosteroids - first report.系统性糖皮质激素治疗后2年皮肤利什曼病复发——首例报告
Int J Dermatol. 2007 Jun;46(6):628-30. doi: 10.1111/j.1365-4632.2006.03096.x.
5
Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.克氏锥虫糖基磷脂酰肌醇（GIPL）的Toll样受体4（TLR4）依赖性促炎和免疫调节特性
J Leukoc Biol. 2007 Sep;82(3):488-96. doi: 10.1189/jlb.0706478. Epub 2007 May 31.
6
NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.内脏利什曼病中自然杀伤细胞的激活需要Toll样受体9、髓样树突状细胞和白细胞介素-12，但不依赖浆细胞样树突状细胞。
J Exp Med. 2007 Apr 16;204(4):893-906. doi: 10.1084/jem.20061293. Epub 2007 Mar 26.
7
Immunology. Mouse studies question importance of toll-like receptors to vaccines.免疫学。小鼠研究对Toll样受体在疫苗中的重要性提出质疑。
Science. 2006 Dec 22;314(5807):1859-60. doi: 10.1126/science.314.5807.1859a.
8
Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation.Toll样受体3的两个酪氨酸残基触发核因子-κB激活的不同步骤。
J Biol Chem. 2007 Feb 9;282(6):3423-7. doi: 10.1074/jbc.C600226200. Epub 2006 Dec 18.
9
Treatment of mucosal leishmaniasis with a lipid formulation of amphotericin B.用两性霉素B脂质制剂治疗黏膜利什曼病。
Clin Infect Dis. 2007 Jan 15;44(2):311-2. doi: 10.1086/510494.
10
Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates.利用热解保护基团防止D型CpG ODN中G-四联体的形成：灵长类动物的结构研究和免疫调节活性
Nucleic Acids Res. 2006;34(22):6488-95. doi: 10.1093/nar/gkl867. Epub 2006 Nov 27.

Toll-like receptors and leishmaniasis.

作者信息

Tuon Felipe F, Amato Valdir S, Bacha Hélio A, Almusawi Tariq, Duarte Maria I, Amato Neto Vicente

机构信息

Infectious and Parasitic Diseases Clinic, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar 255, Sala 4028-ICHC, Cerqueira César, 05403-010, São Paulo, Brazil.

出版信息

Infect Immun. 2008 Mar;76(3):866-72. doi: 10.1128/IAI.01090-07. Epub 2007 Dec 10.

DOI:10.1128/IAI.01090-07
PMID:18070909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2258802/
Abstract
摘要