天然二芳基壬烷类化合物马拉巴酮B和马拉巴酮C在消炎痛诱导的胃溃疡愈合过程中的血管生成和细胞增殖作用。
Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration.
作者信息
Banerjee Debashish, Maity Biswanath, Bandivdeker Atmaram H, Bandyopadhyay Sandip K, Chattopadhyay Subrata
机构信息
Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic medical Sciences and IPGME&R, 244B Acharya Jagadish Chandra Bose Road, Kolkata 700020, India.
出版信息
Pharm Res. 2008 Jul;25(7):1601-9. doi: 10.1007/s11095-007-9512-0. Epub 2007 Dec 11.
PURPOSE
To evaluate the plant phenolics, malabaricone B (mal B) and malabaricone C (mal C) in healing stomach ulcer by modulating angiogenesis.
MATERIALS AND METHODS
Male Swiss albino mice, ulcerated with indomethacin (18 mg/kg, p. o., single dose) were treated up to 7 days with different doses of mal B or mal C. The healing capacities of the drugs and their effects on the angiogenic parameters were assessed.
RESULTS
Maximum ulceration, observed on the 3rd day after indomethacin administration was effectively healed by mal B and mal C (each 10 mg/kg, p. o. x 3 days), the latter showing equivalent potency (~78% p < 0.001) as that of Omez (3 mg/kg, p. o. x 3 days) and misoprostol (10 mug/kg, p. o. x 3 days). Compared to the untreated mice, those treated with mal B or mal C respectively for 3 days increased the mucosal EGF level (139 and 178%, p < 0.001), the serum VEGF level (56%, p < 0.01 and 95%, p < 0.001) and microvessels formation (37%, p < 0.05 and 62%, p < 0.01), while reducing the serum endostatin level (37%, p < 0.05 and 61%, p < 0.01). The relative healing capacities of mal B and mal C correlated well with their respective abilities to modulate the angiogenic factors. The healing by Omez and misoprostol was not due to improved angiogenesis.
CONCLUSIONS
The drugs, mal B and mal C could effectively heal indomethacin-induced stomach ulceration in mice by promoting angiogenesis.
目的
通过调节血管生成来评估植物酚类物质马拉巴酮B（mal B）和马拉巴酮C（mal C）对胃溃疡愈合的作用。
材料与方法
用吲哚美辛（18毫克/千克，口服，单剂量）使雄性瑞士白化小鼠产生溃疡，然后用不同剂量的mal B或mal C治疗7天。评估药物的愈合能力及其对血管生成参数的影响。
结果
吲哚美辛给药后第3天观察到的最大溃疡，被mal B和mal C（各10毫克/千克，口服×3天）有效愈合，后者显示出与奥美唑（3毫克/千克，口服×3天）和米索前列醇（10微克/千克，口服×3天）相当的效力（~78%，p<0.001）。与未治疗的小鼠相比，分别用mal B或mal C治疗3天的小鼠，黏膜表皮生长因子（EGF）水平升高（139%和178%，p<0.001），血清血管内皮生长因子（VEGF）水平升高（56%，p<0.01和95%，p<0.001），微血管形成增加（37%，p<0.05和62%，p<0.01），同时血清内皮抑素水平降低（37%，p<0.05和61%，p<0.01）。mal B和mal C的相对愈合能力与其各自调节血管生成因子的能力密切相关。奥美唑和米索前列醇的愈合并非由于血管生成改善。
结论
mal B和mal C可通过促进血管生成有效治愈吲哚美辛诱导的小鼠胃溃疡。
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