戒断期青少年大麻使用者的空间工作记忆表现与功能磁共振成像激活的相互作用
Spatial working memory performance and fMRI activation interaction in abstinent adolescent marijuana users.
作者信息
Padula Claudia B, Schweinsburg Alecia D, Tapert Susan F
机构信息
Veterans Affairs San Diego Healthcare System, San Diego, USA.
出版信息
Psychol Addict Behav. 2007 Dec;21(4):478-87. doi: 10.1037/0893-164X.21.4.478.
Abstract
Previous studies have suggested neural disruption and reorganization in adult marijuana users. However, it remains unclear whether these effects persist in adolescents after 28 days of abstinence and, if they do, what Performance x Brain Response interactions occur. Adolescent marijuana users (n=17) and controls (n=17) aged 16-18 years were recruited from local schools. Functional magnetic resonance imaging data were collected after 28 days' monitored abstinence as participants performed a spatial working memory task. Marijuana users show Performance x Brain Response interactions in the bilateral temporal lobes, left anterior cingulate, left parahippocampal gyrus, and right thalamus (clusters >/=1358 microl; p<.05), although groups do not differ on behavioral measures of task performance. Marijuana users show differences in brain response to a spatial working memory task despite adequate performance, suggesting a different approach to the task via altered neural pathways.
摘要
以往的研究表明，成年大麻使用者存在神经破坏和重组现象。然而，目前尚不清楚这些影响在青少年戒断28天后是否仍然存在，如果存在，会发生怎样的行为表现与脑反应的相互作用。从当地学校招募了年龄在16 - 18岁的青少年大麻使用者（n = 17）和对照组（n = 17）。在接受28天的戒断监测后，当参与者执行空间工作记忆任务时，收集功能磁共振成像数据。大麻使用者在双侧颞叶、左侧前扣带回、左侧海马旁回和右侧丘脑表现出行为表现与脑反应的相互作用（簇>/=1358微升；p<.05），尽管两组在任务表现的行为指标上没有差异。尽管大麻使用者在任务表现上足够，但他们对空间工作记忆任务的脑反应存在差异，这表明他们通过改变神经通路对任务采取了不同的处理方式。
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