Magalhães Ana Carolina, Rios Daniela, Honório Heitor Marques, Jorge Alberto Moreira, Delbem Alberto Carlos Botazzo, Buzalaf Marília Afonso Rabelo
Department of Child and Social Dentistry, Faculty of Dentistry of Araçatuba, UNESP-São Paulo State University, Rua José Bonifácio, 1193 Araçatuba, SP 16015-050, Brazil.
Arch Oral Biol. 2008 May;53(5):399-404. doi: 10.1016/j.archoralbio.2007.10.011. Epub 2008 Feb 20.
This in situ/ex vivo study assessed the effect of titanium tetrafluoride (TiF(4)) on permanent human enamel subjected to erosion.
Ten volunteers took part in this study performed in two phases. In the first phase (ERO), they wore acrylic palatal appliances containing two enamel blocks, divided into two rows: TiF(4) (F) and no-TiF(4) (no-F). During the 1st day, the formation of a salivary pellicle was allowed. In the 2nd day, the TiF(4) solution was applied on one row (ERO+F), whereas on the other row no treatment was performed (ERO+no-F). From 3rd until 7th day, the blocks were subjected to erosion, 4x per day. In the 2nd phase (no-ERO), the volunteers wore acrylic palatal appliances containing one enamel block, during 2 days, to assess the effect of TiF(4) only (no-ERO+F). Enamel alterations were determined using profilometry (wear), microhardness (%SMHC) tests, scanning electron microscope and microprobe analysis. The %SMHC and wear were tested using ANOVA and Tukey's post hoc tests (p<0.05).
The mean of %SMHC and wear (microm) values (+/-S.D.) were, respectively: ERO+F -73.32+/-5.16(A)/2.40+/-0.60(a); ERO+no-F -83.49+/-4.59(B)/1.17+/-0.48(b) and no-ERO+F -67.92+/-6.16(A)/0.21+/-0.09(c). In microscope analysis, the no-F group showed enamel with honeycomb appearance. For F groups, it was observed a surface coating with microcracks. The microprobe analysis revealed the presence of the following elements (%) in groups ERO+F, ERO+no-F and no-ERO+F, respectively: Ca (69.9, 72.5, 66.25); P (25.9, 26.5, 26.06); Ti (3.0, 0, 5.93).
The TiF(4) was unable to reduce dental erosion.
本原位/离体研究评估了四氟化钛（TiF₄）对遭受酸蚀的人恒牙釉质的影响。
10名志愿者参与了本分为两个阶段进行的研究。在第一阶段（ERO），他们佩戴含两个釉质块的丙烯酸腭部矫治器，釉质块分为两排：TiF₄（F）组和无TiF₄（无F）组。在第1天，让唾液薄膜形成。在第2天，将TiF₄溶液应用于一排（ERO + F），而另一排不进行处理（ERO + 无F）。从第3天到第7天，釉质块每天接受4次酸蚀。在第二阶段（无ERO），志愿者佩戴含一个釉质块的丙烯酸腭部矫治器，持续2天，以评估单独TiF₄的作用（无ERO + F）。使用轮廓仪（磨损）、显微硬度（%SMHC）测试、扫描电子显微镜和微探针分析来确定釉质变化。%SMHC和磨损通过方差分析和Tukey事后检验进行测试（p<0.05）。
%SMHC和磨损（微米）值（±标准差）的均值分别为：ERO + F组 -73.32±5.16（A）/2.40±0.60（a）；ERO + 无F组 -83.49±4.59（B）/1.17±0.48（b）；无ERO + F组 -67.92±6.16（A）/0.21±0.09（c）。在显微镜分析中，无F组的釉质呈现蜂窝状外观。对于F组，则观察到有微裂纹的表面涂层。微探针分析显示ERO + F组、ERO + 无F组和无ERO + F组中分别存在以下元素（%）：钙（69.9、72.5、66.25）；磷（25.9、26.5、26.06）；钛（3.0、0、5.93）。
TiF₄无法减少牙齿酸蚀。
