Trivedi Ranak, Sherwood Andrew, Strauman Timothy J, Blumenthal James A
Box 3119 Duke University Medical Center, Durham NC 27710, United States.
Biol Psychol. 2008 Mar;77(3):317-23. doi: 10.1016/j.biopsycho.2007.11.004. Epub 2007 Nov 17.
The recovery phase of the stress response is an individual difference characteristic that may predict cardiovascular risk. The purpose of this study was to examine whether laboratory-based blood pressure (BP) recovery predicts ambulatory BP (ABP). One hundred and eighty-two participants underwent a standard laboratory stress protocol, involving a 20-min baseline rest period, and four stressors presented in a counterbalanced order, each followed by a 10-min recovery period. Participants also wore an ABP monitor for 24h during a typical workday. Hierarchical regression analyses showed that BP recovery accounted for significant additional variance for daytime SBP (p<0.001), nighttime SBP (p<0.001), daytime DBP (p<0.001), and nighttime DBP (p<0.001), after controlling for baseline and reactivity BP. Results suggest that persistence of the BP response following stress may be a more salient characteristic of the stress response in understanding its potential impact on longer term cardiovascular regulation.
应激反应的恢复阶段是一种个体差异特征,可能预测心血管风险。本研究的目的是检验基于实验室的血压(BP)恢复是否能预测动态血压(ABP)。182名参与者接受了标准的实验室应激方案,包括20分钟的基线休息期,以及以平衡顺序呈现的四种应激源,每种应激源后接10分钟的恢复期。参与者还在一个典型工作日佩戴了24小时动态血压监测仪。分层回归分析表明,在控制了基线血压和反应性血压后,血压恢复对日间收缩压(p<0.001)、夜间收缩压(p<0.001)、日间舒张压(p<0.001)和夜间舒张压(p<0.001)有显著的额外方差解释。结果表明,应激后血压反应的持续性可能是应激反应在理解其对长期心血管调节潜在影响方面更显著的特征。