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爱泼斯坦-巴尔病毒:普通狨猴的实验性感染

Epstein-Barr virus: experimental infection of Callithrix jacchus marmosets.

作者信息

Falk L, Deinhardt F, Wolfe L, Johnson D, Hilgers J, de-Thé G

出版信息

Int J Cancer. 1976 Jun 15;17(6):785-8. doi: 10.1002/ijc.2910170615.

DOI:10.1002/ijc.2910170615
PMID:181333
Abstract

Eight common marmoset monkeys (Callithrix jacchus) were inoculated with about 10(4) transforming units of B95-8 virus; seven of the marmosets died 50-111 days post inoculation and all seven showed microscopic and/or macroscopic lesions compatible with a diagnosis of lymphoproliferative disease. Low levels of anti-VCA antibodies were detected in plasma from six marmosets. Attempts failed to establish continuous EBV-carrying lymphoblastoid cell cultures by cultivation in vitro of circulating lymphocytes or minced lymphoid tissues obtained at necropsy.

摘要

将8只普通狨猴(Callithrix jacchus)接种约10⁴转化单位的B95 - 8病毒;其中7只狨猴在接种后50 - 111天死亡,且这7只均表现出与淋巴增殖性疾病诊断相符的微观和/或宏观病变。在6只狨猴的血浆中检测到低水平的抗VCA抗体。通过体外培养尸检时获得的循环淋巴细胞或切碎的淋巴组织来建立持续携带EBV的淋巴母细胞系培养的尝试均告失败。

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Epstein-Barr virus: experimental infection of Callithrix jacchus marmosets.爱泼斯坦-巴尔病毒:普通狨猴的实验性感染
Int J Cancer. 1976 Jun 15;17(6):785-8. doi: 10.1002/ijc.2910170615.
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Response of marmosets to experimental infection with Epstein-Barr virus.狨猴对爱泼斯坦-巴尔病毒实验性感染的反应。
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In vitro transforming activity of EBV. I-Establishment and properties of two EBV strains (M81 and M72) produced by immortalized Callithrix jacchus lymphocytes.EBV的体外转化活性。I. 由永生化的狨猴淋巴细胞产生的两种EBV毒株(M81和M72)的建立及特性
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Natural antibodies to EBV-VCA antigens in common marmosets (Callithrix jacchus) and response after EBV inoculation.普通狨猴(Callithrix jacchus)中针对EBV-VCA抗原的天然抗体及EBV接种后的反应。
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Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus.接种爱泼斯坦-巴尔病毒后棉顶狨猴发生的恶性淋巴瘤。
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Lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral DNA, and characterization of viruses.接种爱泼斯坦-巴尔病毒后棉顶狨猴发生的淋巴瘤:肿瘤发生率、组织学谱、抗体反应、病毒DNA的检测及病毒特征分析
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Experimental infection of Callithrix Jacchus marmosets with Herpesvirus ateles, Herpesvirus saimiri, and Epstein Barr virus.用蛛猴疱疹病毒、松鼠猴疱疹病毒和爱泼斯坦-巴尔病毒对狨猴进行实验性感染。
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Lymphoproliferative disease in a cotton-top marmoset after inoculation with infectious mononucleosis-derived Epstein-Barr virus.接种传染性单核细胞增多症衍生的爱泼斯坦-巴尔病毒后棉顶狨猴发生的淋巴增生性疾病。
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EB virus: malignant lymphoma in cottontop marmosets following inoculation and recovery of the virus from cells of an experimental tumor maintained in organ culture.EB病毒:棉顶狨猴接种从器官培养中维持的实验性肿瘤细胞所获得的病毒后发生恶性淋巴瘤。
Bibl Haematol. 1975(40):375-83. doi: 10.1159/000397555.

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