Department of Medical Sciences, Section of Dermatology, University of Ferrara, I-44121, Ferrara, Italy.
Contact Dermatitis. 2014 Feb;70(2):90-7. doi: 10.1111/cod.12124. Epub 2013 Aug 2.
The evidence on the safety of topical preparations containing botanical extracts is limited.
To assess (i) the use of botanically derived compounds in a large population, (ii) the incidence of cutaneous side-effects, and (iii) the diagnostic usefulness of patch testing.
A questionnaire was used in 2661 patients to assess both the prevalence and type of topical botanical preparations used, and the occurrence of adverse skin reactions. Patients declaring adverse reactions were patch tested with (i) the Italian (SIDAPA) baseline series, (ii) an additional botanical series, and (iii) the patients' own products.
Of the patients, 1274 (48%) reported the use of topical botanical products; 139 patients (11%) commented on adverse cutaneous reactions; 75 (54%) showed positive reactions with the Italian baseline series. Among the 122 patients tested with the botanical series, 19 (16%) showed positive reactions, in many cases with concomitant relevant positivity to at least one allergen of the Italian series connected with cosmetics. The commonest botanically derived allergens were propolis, Compositae extracts, and Melaleuca alternifolia (tea tree) oil.
Contact allergy is a possible adverse effect of natural products. Baseline series supplemented with the commonest botanical allergens may be adequate for detecting most of the cases of contact allergy to natural topical products.
关于含有植物提取物的局部制剂的安全性证据有限。
评估（i）在大量人群中使用植物衍生化合物，（ii）皮肤副作用的发生率，以及（iii）斑贴试验的诊断价值。
在 2661 名患者中使用问卷评估局部植物制剂的使用频率、类型以及不良反应的发生情况。有不良反应的患者接受斑贴试验，包括（i）意大利（SIDAPA）基础系列，（ii）额外的植物系列，以及（iii）患者自己的产品。
在患者中，1274 名（48%）报告使用了局部植物产品；139 名（11%）患者报告了皮肤不良反应；75 名（54%）对意大利基础系列呈阳性反应。在接受植物系列斑贴试验的 122 名患者中，19 名（16%）呈阳性反应，在许多情况下，与化妆品相关的至少一种过敏原的阳性反应也呈阳性。最常见的植物源性过敏原是蜂胶、菊科提取物和互叶白千层（茶树）油。
接触过敏是天然产品的一种潜在不良反应。基础系列补充常见的植物过敏原可能足以检测到大多数对天然局部产品的接触过敏。
