Schwalb Jason M, Hamani Clement
Department of Neurological Surgery, University of Rochester, Rochester, NY 14642, USA.
Neurotherapeutics. 2008 Jan;5(1):3-13. doi: 10.1016/j.nurt.2007.11.003.
The advancement of electrical stimulation of the central nervous system has been a story of fits and bursts with numerous setbacks. In many ways, this history has paralleled the history of medicine and physics. We have moved from anecdotal observation to double-blinded, prospective randomized trials. We have moved from faradic stimulation to systems that lie completely under the skin and can deliver complex electrical currents to discrete areas of the brain while controlled through a device that is not much bigger than a PDA. This review will discuss how deep brain stimulation has developed into its current form, where we see the field going and the potential pitfalls along the way.
中枢神经系统电刺激的发展历程充满了波折与诸多挫折。在许多方面，这段历史与医学和物理学的历史并行。我们已从轶事观察发展到双盲、前瞻性随机试验。我们已从感应电刺激发展到完全植入皮下的系统，该系统能够在通过一个不比掌上电脑大多少的设备进行控制的同时，向大脑的离散区域输送复杂的电流。本综述将讨论深部脑刺激是如何发展成其当前形式的，该领域的发展方向以及在此过程中可能存在的陷阱。
