Ivanova E A
Ontogenez. 1975;6(6):554-62.
The dynamics of consumption of testosterone-7alpha-3H by different tissues of the differentiating reproductive system, as well as by suprarenals, brain, hypothalamus and muscles was studied in the in vivo experiments with the rat male embryos beginning from the 14th and till the 20th days of development. The specific consumption of the labelled androgen related to the metabolic processes was observed at all developmental stages under study. The selective consumption of testosterone-7alpha-3H was noted prior to the beginning and during the morphogenesis of the organs-targets' rudiments. The radioactivity in tissues increased already 1--2 days following the castration of 18 days old embryos. Estrone, testosterone, testosterone-propionate, cyproterone-acetate competitively decreased the consumption of testosterone-7alpha-3H. The problem of reception of tissues of the rat male embryos to the male sex hormone is discussed.
在对雄性大鼠胚胎从发育第14天至第20天进行的体内实验中，研究了分化中的生殖系统的不同组织以及肾上腺、脑、下丘脑和肌肉对睾酮-7α-³H的摄取动态。在所有研究的发育阶段都观察到了与代谢过程相关的标记雄激素的特异性摄取。在器官-靶标的原基开始形成之前和形成过程中，发现了睾酮-7α-³H的选择性摄取。对18天大的胚胎进行阉割后1-2天，组织中的放射性就已增加。雌酮、睾酮、丙酸睾酮、醋酸环丙孕酮竞争性地降低了睾酮-7α-³H的摄取。讨论了雄性大鼠胚胎组织对雄性激素的接受问题。
