Ivanova E A
Ontogenez. 1982 Mar-Apr;13(2):169-75.
The dynamics of testosterone-1 alpha, 2 alpha-3H(n) intake by different tissues of genital tract was studied in the guinea pig embryos from the 23rd day of development till birth. The specific intake was noted at all developmental stages studied and in all genital tract rudiments. The Selective intake was observed in the male embryos in the genital tubercle from the 29th day, in the ducts from the 46th day and in the urogenital sinus from the 26th day. In the female embryos it was found in the genital tubercle on the 26--28th day and from the 35th, in the ducts from the 46th day and in the urogenital sinus on the 32--35th, 46--50th days and prior to birth. The specific intake was also observed in the gonads of embryos of both sexes. The data obtained suggest the presence of reception to androgen prior to the beginning of morphogenesis of the genital system and the acquisition of increase sensitivity to the hormone in the homologous rudiments during the critical periods of differentiation of organ targets by the male type.
在豚鼠胚胎发育的第23天直至出生期间，研究了睾酮-1α，2α-3H(n)被生殖道不同组织摄取的动态情况。在所有研究的发育阶段以及所有生殖道原基中均观察到了特异性摄取。在雄性胚胎中，从第29天起在生殖结节中、从第46天起在管道中以及从第26天起在泌尿生殖窦中观察到了选择性摄取。在雌性胚胎中，在第26 - 28天以及从第35天起在生殖结节中、从第46天起在管道中以及在第32 - 35天、第46 - 50天以及出生前在泌尿生殖窦中发现了选择性摄取。在两性胚胎的性腺中也观察到了特异性摄取。所获得的数据表明，在生殖系统形态发生开始之前就存在雄激素受体，并且在器官靶标按雄性类型分化的关键时期，同源原基对该激素的敏感性增加。
