Simonsson T, Hvid E B, Rundegren J, Edwardsson S
Biology Department, School of Dentistry, Malmö, Sweden.
Oral Microbiol Immunol. 1991 Oct;6(5):305-9. doi: 10.1111/j.1399-302x.1991.tb00498.x.
This study investigated the effect of a surface active compound, delmopinol, on plaque formation and established plaque in vitro, on the bacterial acid production from glucose and on the total viable bacterial counts in saliva. The antimicrobial effect was compared with that of chlorhexidine. The plaque-inhibiting effect was evaluated in an artificial mouth system, and the effect on bacterial acid production was registered as a decrease of pH in bacterial suspensions with various concentrations of delmopinol. It was shown that delmopinol is able to prevent plaque formation, to dissolve established plaque in vitro, and that it has 5-125 times higher minimum inhibitory concentrations than chlorhexidine. Saliva samples collected 1 min after rinsing with delmopinol showed on differences in the total number of bacteria in saliva as compared with controls. It was also shown that the bacterial acid production from glucose was reduced successively with increasing concentrations of delmopinol. The results indicate that delmopinol might be as effective as chlorhexidine against plaque formation and that delmopinol is capable of penetrating established plaque, thus promoting a more effective mechanical cleansing.
本研究调查了表面活性化合物地莫匹醇对体外菌斑形成和已形成菌斑的影响，对葡萄糖产酸的影响以及对唾液中细菌活菌总数的影响。将其抗菌效果与氯己定进行了比较。在人工口腔系统中评估了其抑制菌斑的效果，并将其对细菌产酸的影响记录为在含有不同浓度地莫匹醇的细菌悬液中pH值的降低。结果表明，地莫匹醇能够预防菌斑形成，在体外溶解已形成的菌斑，并且其最低抑菌浓度比氯己定高5至125倍。用地莫匹醇漱口1分钟后采集的唾液样本显示，与对照组相比，唾液中细菌总数无差异。还表明，随着地莫匹醇浓度的增加，葡萄糖的细菌产酸量依次降低。结果表明，地莫匹醇在预防菌斑形成方面可能与氯己定一样有效，并且地莫匹醇能够穿透已形成的菌斑，从而促进更有效的机械清洁。
