系统性红斑狼疮和类风湿关节炎中B细胞活化的可能不同机制：其外周血B细胞上IgE低亲和力受体（CD23）的相反表达。
Possible different mechanisms of B cell activation in systemic lupus erythematosus and rheumatoid arthritis: opposite expression of low-affinity receptors for IgE (CD23) on their peripheral B cells.
作者信息
Kumagai S, Ishida H, Iwai K, Tsubata T, Umehara H, Ozaki S, Suginoshita T, Araya S, Imura H
机构信息
Second Division of Internal Medicine, Kyoto University Medical School, Japan.
出版信息
Clin Exp Immunol. 1989 Dec;78(3):348-53.
To clarify the differential state of B cell activation in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), we investigated the expression of low-affinity receptor for IgE (Fc epsilon RII; CD23) on their peripheral B cells by a cytofluorometry using H107 (CD23) and Leu-16 (CD20) monoclonal antibodies. The percentage of CD23-negative B cells in total lymphocytes was significantly greater in both groups of patients than in normal subjects, suggesting the hyperactivity of late-phase B cells in both diseases. However, the increase of CD23-negative B cells in RA was brought about by the increased number of total B cells, although that in SLE was mainly based on the relative decrease of CD23-positive B cells. The number of IgD-positive B cells was decreased, and the number of colony-forming B cells was markedly increased in SLE patients. These observations indicate that a B cell abnormality is mainly qualitative in SLE but quantitative in RA.
为阐明系统性红斑狼疮（SLE）和类风湿关节炎（RA）患者B细胞活化的差异状态，我们使用H107（CD23）和Leu-16（CD20）单克隆抗体，通过细胞荧光术研究了其外周血B细胞上IgE低亲和力受体（FcεRII；CD23）的表达。两组患者总淋巴细胞中CD23阴性B细胞的百分比均显著高于正常受试者，提示两种疾病中晚期B细胞均处于高活性状态。然而，RA中CD23阴性B细胞的增加是由于总B细胞数量增加所致，而SLE中CD23阴性B细胞的增加主要是基于CD23阳性B细胞的相对减少。SLE患者中IgD阳性B细胞数量减少，集落形成B细胞数量显著增加。这些观察结果表明，SLE中的B细胞异常主要是定性的，而RA中的B细胞异常主要是定量的。
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