Haedersdal Merete, Togsverd-Bo Katrine, Wiegell Stine Regin, Wulf Hans Christian
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
J Am Acad Dermatol. 2008 Mar;58(3):387-94. doi: 10.1016/j.jaad.2007.11.027.
Long-pulsed dye laser (LPDL)-assisted photodynamic therapy has been suggested to be superior to laser alone for acne vulgaris but no evidence is available.
To evaluate the efficacy and safety of LPDL alone versus LPDL in photodynamic therapy with methylaminolevulinic acid (MAL-LPDL) for acne vulgaris.
Fifteen patients received a series of 3 full-face LPDL treatments and half-face prelaser MAL treatments; the latter being randomly assigned to the left or right side.
Inflammatory lesions were reduced more on MAL-LPDL-treated than on LPDL-treated sides (week 4: 70% vs 50%, P = .003; week 12: 80% vs 67%, P = .004). Noninflammatory lesions reduced similarly. Patient satisfaction was slightly greater with MAL-LPDL versus LPDL treatments (scale 0-10: week 4: 7 vs 6, P = .034; week 12: 8 vs 7.5, P = .034). Fluorescence measurements detected photobleaching with MAL-LPDL (35.3%) and LPDL (7.3%) treatments (P < .001). Erythema, edema, and pustular eruptions intensified from MAL incubation. No patients experienced pigment changes or scarring.
The sample size was limited. The split-face design in this randomized controlled trial does not allow us to draw conclusions about the efficacy of the LPDL, only about the efficacy of MAL-LPDL compared with LPDL alone.
MAL-LPDL is slightly superior to LPDL for the treatment of inflammatory acne.
长脉冲染料激光（LPDL）辅助光动力疗法被认为治疗寻常痤疮比单纯激光治疗更具优势，但尚无证据支持。
评估单纯LPDL与LPDL联合甲基氨基乙酰丙酸光动力疗法（MAL-LPDL）治疗寻常痤疮的疗效和安全性。
15例患者接受了一系列3次全脸LPDL治疗以及半脸激光前MAL治疗；后者随机分配至左侧或右侧。
MAL-LPDL治疗侧的炎性皮损减少程度大于LPDL治疗侧（第4周：70%对50%，P = 0.003；第12周：80%对67%，P = 0.004）。非炎性皮损减少程度相似。MAL-LPDL治疗的患者满意度略高于LPDL治疗（0-10分制：第4周：7分对6分，P = 0.034；第12周：8分对7.5分，P = 0.034）。荧光测量检测到MAL-LPDL（35.3%）和LPDL（7.3%）治疗后有光漂白现象（P < 0.001）。MAL孵育后红斑、水肿和脓疱性发疹加重。无患者出现色素改变或瘢痕形成。
样本量有限。该随机对照试验中的半脸设计不允许我们得出关于LPDL疗效的结论，只能得出MAL-LPDL与单纯LPDL相比的疗效结论。
MAL-LPDL治疗炎性痤疮略优于LPDL。
