Bender Bruce G, Ballard Robert, Canono Beth, Murphy James R, Leung Donald Y M
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
J Am Acad Dermatol. 2008 Mar;58(3):415-20. doi: 10.1016/j.jaad.2007.10.010.
The relationship between sleep quality and disease severity in patients with atopic dermatitis has not been clearly defined.
Sleep efficiency and scratching were measured over 2 nights by polysomnography, actigraphy, and self-report in 20 adults with atopic dermatitis. Tumor necrosis factor, interleukin (IL)-6, and IL-10 were assayed from a subset of 9 participants.
Sleep measured by actigraphy and polysomnography were strongly associated with each other. Decreased sleep efficiency was associated with increasing disease severity, scratching, and IL-6. Self-reported sleep quality and quality of life were not significantly correlated with either objective sleep measure.
Results in this pilot study await confirmation in a larger investigation.
Objective measures but not self-report documented that increasing severity of atopic dermatitis results in more scratching and declining sleep quality. Our data also suggest an important relationship between sleep and IL-6.
特应性皮炎患者的睡眠质量与疾病严重程度之间的关系尚未明确界定。
通过多导睡眠图、活动记录仪和自我报告对20名成年特应性皮炎患者进行了两晚的睡眠效率和搔抓情况测量。对9名参与者的子集进行了肿瘤坏死因子、白细胞介素（IL）-6和IL-10的检测。
通过活动记录仪和多导睡眠图测量的睡眠彼此密切相关。睡眠效率降低与疾病严重程度增加、搔抓和IL-6升高有关。自我报告的睡眠质量和生活质量与任何一种客观睡眠测量均无显著相关性。
本初步研究的结果有待在更大规模的调查中得到证实。
客观测量而非自我报告表明，特应性皮炎严重程度增加会导致更多搔抓和睡眠质量下降。我们的数据还表明睡眠与IL-6之间存在重要关系。
