伯氏疏螺旋体在莱姆关节炎中激活一类1型辅助性T细胞亚群。
Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.
作者信息
Yssel H, Shanafelt M C, Soderberg C, Schneider P V, Anzola J, Peltz G
机构信息
Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303.
出版信息
J Exp Med. 1991 Sep 1;174(3):593-601. doi: 10.1084/jem.174.3.593.
Abstract
18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease.
摘要
从四名慢性莱姆关节炎患者中分离出18个与伯氏疏螺旋体蛋白反应的克隆T细胞系，所有细胞均为CD3 + 4 + 8 - TCR - α/β + ，并受HLA II类蛋白限制。对这些T细胞克隆的分析表明，T细胞对莱姆病螺旋体的反应并非寡克隆受限；然而，在抗原特异性或非特异性刺激后，所有细胞产生的细胞因子模式相同，类似于小鼠1型辅助性T细胞。因此，具有独特细胞因子分泌谱的人类CD4 + T细胞亚群被引发这种慢性炎症性疾病的病原体选择性激活。
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