Division of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UK.
Division of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UK
BMJ Open. 2021 Jul 22;11(7):e044676. doi: 10.1136/bmjopen-2020-044676.
Means-based analysis of maximal rate of oxygen consumption (VO) has traditionally been used as the exercise response indicator to assess the efficacy of endurance (END), high intensity interval (HIIT) and resistance exercise training (RET) for improving cardiorespiratory fitness and whole-body health. However, considerable heterogeneity exists in the interindividual variability response to the same or different training modalities.
We performed a systematic review and meta-analysis to investigate exercise response rates in the context of VO: (1) in each training modality (END, HIIT and RET) versus controls, (2) in END versus either HIIT or RET and (3) exercise response rates as measured by VO versus other indicators of positive exercise response in each exercise modality.
Three databases (EMBASE, MEDLINE, CENTRAL) and additional sources were searched. Both individual response rate and population average data were incorporated through continuous data, respectively. Of 3268 identified manuscripts, a total of 29 studies were suitable for qualitative synthesis and a further 22 for quantitative. Stratification based on intervention duration (less than 12 weeks; more than or equal to 12 weeks) was undertaken.
A total of 62 data points were procured. Both END and HIIT training exhibited differential improvements in VO based on intervention duration. VO did not adequately differentiate between END and HIIT, irrespective of intervention length. Although none of the other exercise response indicators achieved statistical significance, LT and HR demonstrated common trajectories in pooled and separate analyses between modalities. RET data were highly limited. Heterogeneity was ubiquitous across all analyses.
The potential for LT and HR as indicators of exercise response requires further elucidation, in addition to the exploration of interventional and intrinsic sources of heterogeneity.
最大摄氧量（VO）的基于均值的分析一直被用作评估耐力（END）、高强度间歇训练（HIIT）和抗阻训练（RET）对改善心肺适应性和整体健康的功效的运动反应指标。然而，在相同或不同训练方式下，个体间的变异性反应存在很大差异。
我们进行了一项系统评价和荟萃分析，以研究 VO 背景下的运动反应率：（1）在每种训练方式（END、HIIT 和 RET）与对照组之间，（2）在 END 与 HIIT 或 RET 之间，以及（3）通过 VO 测量的运动反应率与每种运动方式中其他积极运动反应指标的比较。
检索了三个数据库（EMBASE、MEDLINE、CENTRAL）和其他来源。分别通过连续数据纳入个体反应率和群体平均数据。在 3268 篇鉴定的文献中，共有 29 项研究适合定性综合分析，另有 22 项适合定量分析。根据干预持续时间（少于 12 周；多于或等于 12 周）进行分层。
共获取了 62 个数据点。END 和 HIIT 训练均表现出基于干预持续时间的 VO 差异改善。无论干预时间长短，VO 均不能充分区分 END 和 HIIT。尽管其他运动反应指标均未达到统计学意义，但 LT 和 HR 在模式间的 pooled 和单独分析中表现出共同的趋势。RET 数据非常有限。所有分析均存在广泛的异质性。
LT 和 HR 作为运动反应指标的潜力需要进一步阐明，同时还需要探讨干预和内在异质性的来源。
